103b esophagus pathology Flashcards
dyspagia
difficultly swallowing
odynophagia
painful swallowing
dyspepsia
indigestion
esophagus cell type and basal layer thickness
non-keratinized stratified squamous epithelium
15% (<50% for papilla)
where are glands and lympahtics located in the esophagus?
submucosa
what is the z line?
GE junction b/w columnar epithelium of stomach and non-keratinized statified squadmos epi of esophagus
which is darker staining in the esophagus - smooth or skeletal muscle?
skeletal is darker
reflux esophagitis definition
inflammatory process
reflux of gastric/dueodenal contents
failure of anti-reflux mechanisms (not belching or vomiting)
predisposing factors for RE
symptoms of PE
hiatus hernia
pyloric stenosis
increased intraabdominal P
symptoms - heart burn, painful swallowing, bleeding
RE pathogenesis and complications
low LES tone
increased gastic empting time
antral gastritis
complications - ulcers, strictures, barrett’s esophagus
RE endoscopic findings
nothing 50% of time
hyperemia
white plaques from keratin formation
RE histo
basal cell hyperplasia
vascular papillae extension to surface
inflam. cels (PMNs, eosinophils)
Eosinophilic esophagitis morphology
> 15 intraepithelial eosinophils in 2 or HPF
25 in any HPF
lamina propria fibrosis
EoE presentation
majority have dysphagia with food getting stuck due to muscle dysfunction as a result of lamina propria fibrosis
EoE treatment
removal of allergic etiology
steroids