10 Regulation of Food Intake Flashcards
What are the distinct populations within the arcuate nucleus
POMC/CART (anorexigenic)
Neuropeptide Y/AgRP (orexigenic)
What stimulates the POMC and inhibits NPY-AGRP pathway? What is the result?
Leptin; decreased food intake
POMC neurons suppress appetite with _________
α melanocyte stimulating hormone (α-MSH)
What does ghrelin activate
AGRP-NPY neurons to stimulate food intake
Orexigenic effects are mediated through __ receptors of ____
Y1; NPY
AGRP and NPY _______________ and ___________, causing weight gain
Stimulate food intake; decrease energy expenditure
Mutations in what gene have been seen to cause obesity
α MSH receptor = MC4R and MC3R
What is the vagus n role in satiety and feeding
It coordinates the physiology of eating
What does ghrelin do?
- stimulates appetite through NPY secreting neurons
- increases GH secretion
What produces leptin
Fat cells
What does leptin do
Suppresses ghrelin
Stimulation of leptin receptors initiates what
- decreased production of NPY and AGRP
- activation of POMC neurons causing a release of αMSH
- increased production of corticotropin-releasing hormone (decreases food intake)
- increased sympathetic activity (increases metabolic rate and energy expenditure)
- decreased insulin secretion
Insulin can bind to the ________ where it helps to control food intake
Hypothalamus
What does CCK do
- gallbladder contraction
- gut motility
- gastric emptying
- decrease acid
What does PPY do
Peptide that increases while feeding causing decreased apetite
