0 Intro to GI Phys Flashcards
1
Q
Where is somatostatin secreted
A
D cells
2
Q
What stimulates somatostatin
A
Decreased luminal pH
3
Q
What does somatostatin do
A
Inhibits gastric H secretion
Inhibits secretion of other GI hormones
4
Q
Where is somatostatin secreted outside GI
A
Hypothalamus + delta cells
5
Q
What does histamine do in the stomach
A
Stimulates acid production
6
Q
What secretes histamine in the stomach
A
Enterochromaffin-like cells
7
Q
What is the target of histamine
A
Parietal cells
8
Q
What does gastrin do
A
Increase in gastric H secretion
Stimulates growth of gastric mucosa
9
Q
What does CCK do
A
- Increase pancreatic enzyme
- Increase pancreatic HCO3
- Stimulates contraction of the gallbladder and relaxes sphincter of Oddi
- Inhibits gastric emptying
10
Q
What does secretin do
A
- increase pancreatic HCO3 secretion
- increase biliary HCO3 secretion
- decrease gastric H secretion
- inhibits trophic effect of gastrin
11
Q
What is the action of GIP
A
- increase insulin secretion from pancreatic β cells
- decrease gastric H secretion
12
Q
GIP directly stimulates what pancreatic cells
A
β
13
Q
What does ACh do
A
- contraction of smooth muscle
- relaxation of sphincters
- increase salivary secretion
- increase gastric secretion
- increase pancreatic secretion
14
Q
What does NE do in the GI
A
- relaxation of SM
- contraction of sphincters
- increase salivary secretion
15
Q
What does VIP do
A
- relaxation of SM
- increase intestinal secretion
- increase pancreatic secretion
