10. integration in the NS

Question 1

Membrane resistance (Rm) =

Answer 1

V/I

Question 2

Membrane Capacitance (Cm)

Answer 2

Cm ~ 1μF/cm2

Question 3

How is glutamate release at the neocortical and hippocampal nerve terminals modulated?
Excitatory
Inhibitory
Feedback methods (2)

Answer 3

Excitatory input is mediated by APs
Major inhibitory input is mediated
by  GABAB receptors
Feedback is provided by metabotropic 
glutamate receptors
Feedback can also be provided by ATP 
(and adenosine), co-released with Glu
and released from glial cells as well

Question 4

What are the two modes of glia-neuron integration?

Answer 4

1. Astrocytes modulate signalling
   in the tripartite synapses and synchronize
   activity of local neuronal networks
2. Astrocytes mediate neuro-vascular coupling
   and regulate metabolic support of neurons
   “on demand” (i.e. depending on their activity)