1. Development of the NS

Question 1

4 disabilities which occur in spina bifida

Answer 1

paralysis of legs
loss of bowel and bladder control
hydrocephalus (water on brain)
learning disabilities

Question 2

What can result from ineffective neural tube closure?

Answer 2

anencephaly
spina bifida
encephalocele
meningomyocephale

Question 3

3 signals from the mesoderm that prevent the ectodermal fate

Answer 3

Chordin
Follastatin
Noggin

Question 4

What preserved the ectodermal fate?

Answer 4

BMP

Question 5

4 Transcription factors which control compartmentalisation

Answer 5

Hox
Krox20
Otx
Emx2

Question 6

Explain lateral inhibition

Answer 6

Cells compete to adopt a neural fate

Question 7

Which ligand and receptor are involved in lateral inhibition and how does it work?

Answer 7

Delta (ligand) and Notch (receptor)

If a cell express high delta and low notch it becomes a neuron