10. Hypothyreose Flashcards

1
Q

(Hypothyreose)

häufigste Ursache

A

autoimmune Genese (i.d.R. Morbus Hashimoto)

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2
Q

(Hypothyreose)

Einteilung (3)

A
  • primäre (thyreogene)
  • sekundäre (hypophysäre)
  • tertiäre (hypothalamische)
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3
Q

(Hypothyreose)

primäre: Ursache

A

Mangel an FT4

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4
Q

(Hypothyreose)

sekundäre: Ursache

A

Mangel an TSH

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5
Q

(Hypothyreose)

tertiäre: Ursache

A

Mangel an TRH

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6
Q

(Hypothyreose)

Komplikationen (2)

A
  • Hyperlipidämie
  • Myxödemkoma
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7
Q

(Hypothyreose)

Hyperlipidämie: Pathophysiologie

A

reduzierte Expression von LDL-Rezeptoren an den Leberzellen

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8
Q

(Hypothyreose)

Sonografie: Indikationen (2)

A

bei auffälligem Palpationsbefund oder Hashimoto-Thyreoiditis

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8
Q

(Hypothyreose)

Labor (4)

A
  • TSH
  • fT4/fT3
  • TRAK
  • anti-TPO
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9
Q

(Hypothyreose)

Bildgebung der Wahl

A

Sonografie

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10
Q

(Hypothyreose)

medikamentöse Therapie der Wahl

A

Hormonsubstitution mit Levothyroxin

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11
Q

(Hypothyreose)

absolute Indikation zur L-Thyroxin-Substitution

A
  • manifeste Hypothyreose
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12
Q

(Hypothyreose)

Indikationen zur L-Thyroxin-Substitution bei latenter Hypothyreose (2)

A
  • TSH > 20

oder

  • TSH < 10 und Alter < 75 Jahre
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