10-31 L3 Depression Mania Flashcards
1
Q
inhibition of MAO via MAOI results in what
A
- less degradatino of NE
- more NE in vesicles
- more NE in synapse
- enhanced transmission
- Increase HR
- Increased BP
- increased flight or fight
2
Q
Are all drugs used to treat depression/manin called ‘antidepressants’ or ‘antimanics’
A
NO!
3
Q
What drugs can alleviate depression (releases monoamines)
MAT
A
- MAOIs (increase monoamines)
- Amphetamin (releases monamines)
- TCAs (enhance monoaminergic transmission)
4
Q
What 2 drugs can cause depression?
A
- Reserpine (depletes monamines)
- Clonidine, alpha-methyldopa (decrease monoamine release)
5
Q
what are the dangers of TCA,s MAOIs, and SSRIs/SNRIs
A
- TCAs: most dangerous risk is cardiac (ANS, BP, HP)
- **MAOIs: **most dangerous risk is HTN crisis from dietary amines
- SSRIs/SNRIs: above dangers are absent (GI and sexual side effets are very common)
6
Q
Black box warning
A
the stongest advice the FDA can provide
7
Q
Lithum
- moa
- therapeutic window
- what happens with low Na
- Drug-drug interactions
A
- MOA: inhibit phosphoinositide signaling from G-protein coupled receptors
- Therapeutic window: 2-3
- low Na makes Li more toxic
- Drug-drug interactions, esp. with renal drugs
8
Q
Which drugs are teratogenic? (VLC)
A
- Valproic acid
- Lithium
- Carbamazepine
9
Q
Carbamazepine (anticonvulsant)
- MOA
- TI
- Drug-drug
- AE
A
- MOA: inhibits VSSC (voltage sensitive sodium channels)
- TI: 2-3 weeks (induces hepatin metabolism of itself
- drug-drug interactions at level of hepatic metabolim
- AE
- neurologic effects
- GI complaints
- decreased blood cells
- risk of serious skin reactions in HLA-B58 patients
10
Q
Valproic acid (anticonvulsant)
- MOA:
- drug-drug
- AE
A
- MOA: inhibibts Na and Ca chanells, enhanced inhibitiory action of GABA
- drug-drug: interactions due to high serum protein binding
- AE:
- GI complaints
- ratre hepatic problems
- tremor
- sedation
