10-10 L2 Pathophysiology and treatment Flashcards
The major mechanism of stroke is:
- Large vessel (50%):
- stenosis of the large artery in the territory of the stroke
The two possible mechanism of Large vessel stroke are:
- artery to artery embolus
- hemodynamic failure
penumbra
injured but potentially salvageable tissue
CHAD2
- Chronic Heart failure,
- HTN,
- Age >75,
- Diabetes,
- Ischemie stoke of TIA (2)
Cererbral amyloid angiopathy
- lobar ICH,
- associated with Apo E2/E4,
- applegreen bifibringence
AVM (Arteriovenous malformation)
arteries and connecting veins to veins without intervening capillary bed and usually abnormal brain tissue.
Cavernous angiomas
Clusters of dilated capillaries without any intervening brain
Venous malformations (venous angiomas)
Enlarged but functional draining veins
Telangiectasias
Enlarged, ectatic capillaries
What type of hemorrhage is present the most in population based autopsy?
Venous angioma
What type of hemorrhage is present the most in ICH patients autopsy?
Arteriovenous malformation
What is the most often cause of a subarachnoid hemorrhage?
saccular (berry) aneurysm
What is the most attributabler risk for SAH?
smoking
What is (are) the clinical presentation of SAH?
- Thunderclap headache,
- (loss of conciousness, vomiting, vertigo, nausea, meningeal signs),
- CT scan will detect 95% of SAH (If stonge suspicion but negative CT,
- check lumbar puncture, Xanthrochromia develops after 6-12 days and lasts a few weeks.
What are some complications after SAH?
- Cardiac dysfunction
- Acute hydrocephalus
