10-09 L2 Tumors of CNS Flashcards
What disease has a WHO grade II, a hypercellular population of naked nuclei with fibrillary processes, replacing the myelin?
Fibrillary astrocytoma
What disease has a WHO grade III, with increased cellularity, nuclear pleomorphism and mitotic figures?
Anaplastic astrocytoma
What is a feature used for grading astrocytoma (this process is probably related to angiogenic factos released by tumors cells).?
Vascular endothelial proliferation
What disease is composed of monotonous cells with a ‘halo’ or ‘fried-egg’ empty space around the nucleii?
Oligodendroglioma
What disease is associated with setting sun sign?
Parinaud’s syndrome
What organ is involved in parinaud’s syndrome
Pineal gland
What two factors are associated with Parinuad’s syndrome?
- hydrocephalus
- setting sun sign (due to tumor compression of the tectum).
What tumor is dural based (extra-axial)?
Meningioma
what histological finding is associated with meningiomas?
psammoma bodies
What is casued by fourth ventrile tumor?
obstructive (“non=communincating”) hydrocephalus
What is usually seen in Ependymoma?
- true rosettes (numerous round monotonous cells which form tubules)
- perivascular pseudorosettes (clearings around vessels)
What is a malignant tumor consisting of primitive neural cells with necrosis CSF (seeding is common)?
Medullobastoma
What is another name for juvenile cerebellar astrocytoma?
pilocytic astrocytoma
Smear cytology prep is usd for seeing what?
pilocytic astocytoma
What is pilocytic astrocytoma
glial cells with round/spinled nuclei and long bipolar processes (“hair=like”)
