10-09 L3 Treatment of tumors (CNS)

Question 1

What are the most common tumors in children?

Answer 1

(0-4) Embronal/medulloblastoma (WHO grade I)

5-14) Pliocytic astrocytoma (WHO grade I

Question 2

What are the most common tumors in adults?

Answer 2

(15-34) Pituitary

(35-85+) Meningioma

Question 3

Distribution of all primary brain and CNS tumors?

Answer 3

Meningioma (34.4%), Glioblastoma (16.7%)

Question 4

Gliomas account for (% of) all tumors and (% of) all malignant tumors

Answer 4

31% of all tumors

80% of malignant tumors

Question 5

Which two tumors can be removed and the pt is able to do fine?

Answer 5

Pilocytic astrocytoma

Meningioma

Question 6

What type of tumors if you remove them will cause long term problems?

Answer 6

Astrocytoma (Grade II & III)
Medulloblastoma Grade IV PNET
Glioblastoma (Grade IV, astrocytoma)

Question 7

What are the two common treatments for brain tumors?

Answer 7

Fractionated 
Stereotactic (used for metastatic tumor)

Question 8

What special consideration must you have for Medulloblastoma?

Answer 8

Need to perform a craniospinal RT (children will 1 yr of additional chemotherapy).

Question 9

Surgery for glioblastoma was surveyed to have the best outcome with what?

Answer 9

chemotherapy (temozolomide) + Radiation therapy

Question 10

What is used to treat primary central nervous system lymphoma?

Answer 10

Methtrexate

Question 11

Tumors often metastasize to the brain from where?

Answer 11

(most) lung and breast

(least) prostate and ovary