1 - The Nervous System Flashcards

1
Q

Branches of the nervous system

A

Central Nervous System (CNS)

Peripheral Nervous System (PNS)

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2
Q

Branches of the CNS and PNS

A

CNS

  • Brain
  • Spinal Cord

PNS

  • Motor Neurons (from CNS to muscles and glands)
  • Sensory Neurons (from sensory organs to CNS)
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3
Q

Branches of motor neurons

A

Somatic Nervous System
- voluntary movements

Autonomic Nervous System
- involuntary responses

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4
Q

Branches of the Autonomic Nervous system

A

Sympathetic Division
- Fight or Flight

Parasympathetic Division
- Rest or Digest

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5
Q

Anatomical Planes (5)

A
Medial Plane
Lateral Plane
Horizontal Plane
Coronal Plane
Sagittal Plane
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6
Q

Ipsilateral and Contralateral

A

Ipsilateral items lie on the same lateral side

Contralateral items lie of different sides of the body

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7
Q

Anatomical Relationships (spatial) (4)

A
Rostral = up (beak)
Caudal = down (tail)

Ventral (anterior) = belly
Dorsal (posterior) = back

These axes line up when you look up, so in normal anatomical position, for the head:
Dorsal = superior
Ventral = inferior

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8
Q

Basic Divisions of the brain (3)

A

Forebrain
Midbrain
Hindbrain

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9
Q

10% of brain volume but 50% of the brain’s cells

A

Cerebellum

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10
Q

Divisions of the Forebrain

A
  • Telencephalon
    > olfactory bulbs (for olfactory stimuli)
    > cerebral hemispheres (regulation of sensory and motor function)
  • Diencephalon (sensory gateway / regulation of internal environment)
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11
Q

Divisions of the Hindbrain

A
  • Cerebellum
    (movement coordination / learning of motor skills)
  • Pons
    (relay point between cerebellum and cerebral cortex in mammals)
  • Medulla
    (regulation of internal environment)
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12
Q

Divisions of the Midbrain

A
  • Optic Tecta
    (processing of sensory {mainly visual} stimuli)
  • Tegmentum
    (aspects of motor control)
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13
Q

Divisions of the cortex into lobes (forebrain)

A

Frontal Lobe

  • motor control
  • executive functions

Temporal Lobe
- hearing

Parietal Lobe

  • bodily sensations
  • spatial relationships

Occipital Lobe
- vision

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14
Q

Brodmann’s areas

A

Divided the brain into areas according to structural divisions
However an apparent difference in structure does not mean a difference in function

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15
Q

Cranial Nerves

A

The structures that carry information into the brain
There are 12 cranial nerves in humans, the first 2 emerge from the cerebrum and the other 10 emerge from the brainstem

Cranial Nerves are part of the Peripheral Nervous System (sensory neurons)

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16
Q

Overview of brain functions:

  • cerebral cortex
  • basal ganglia
  • thalamus, hypothalamus
  • cerebellum
  • pons and medulla
  • midbrain
A

Cerebral cortex

  • cognition
  • sensory processing
  • motor control
  • learning

Basal Ganglia
- voluntary and learnt motion

Thalamus, Hypothalamus

  • sensory integration and relay
  • attention
  • consciousness
  • emotion
  • homeostasis

Cerebellum

  • motor coordination
  • muscle tone and balance

Pons and Medulla

  • involuntary body functions (i.e. sleep)
  • cognitive motor skills (i.e. typing)

Midbrain

  • audio/visual relay
  • posture
  • alertness
17
Q

Ganglia

A

A group of related nuclei

18
Q

Divisions of the spinal cord and what they innervate

A

8 Cervical nerves
- neck / shoulders / arms / hands

12 Thoracic nerves
- trunk of the body / arms

5 Lumbar nerves
- lower back / front of the legs

5 Sacral nerves
- back of legs + ass / genitals

19
Q

Dorsal column-medial lemniscal pathway

A

Transmits sensory information but NOT pain
- from proprioceptors or mechanoreceptors

Pathway:

  • Afferent (first-order) neuron from the receptor goes into the dorsal root ganglion of the spinal cord
  • Passes up the Dorsal Column to the Medulla Oblongata, where it synapses onto a second-order
  • 2nd order neuron travels out of the Dorsal Column and passes over the Medial-Lemniscus to the other side of the Medulla Oblongata and up into the Thalamus
  • In the Thalamus, it synapses onto a third-order neuron and terminates in the Primary Somatosensory Cortex
20
Q

Spinothalamic Tract (a pathway)

A

Transmits pain information
- from nociceptors or thermoreceptors

Pathway:

  • Afferent neuron from the receptor goes into the dorsal root ganglion of the spinal cord
  • Immediately synapses onto an interneuron in the dorsal horn and passes into the other side of the spinal cord
  • This travels up to the thalamus where it synapses onto an efferent neuron and onto the Primary Somatosensory Cortex
21
Q

What the dorsal column-medial lemniscal pathway and spinothalamic tract tell you about spinal damage

A

If damaged on one side of the spina cord:

  • sensory information from below that same side will not travel up
  • pain information from that opposite side will not travel up
  • due to the way each pathway passes over to the other side of the spinal cord
22
Q

Sympathetic vs Parasympathetic effects of the Autonomic Nervous System

A

Sympathetic

  • dilates pupils and inhibits tears
  • relaxes airways
  • increases heart rate
  • inhibits salivation and digestion / stimulates glucose release from the liver
  • relaxes bladder and rectum
  • stimulates orgasm
  • stimulates release of adrenalin and noradranalin

Parasympathetic

  • constricts pupils an stimulates tears
  • constricts airways
  • slows heart rate
  • stimulates salivation and digestion / stimulates insulin release from the liver
  • constricts bladder and rectum
  • stimulates sexual arousal
23
Q

Changes to the Autonomic Nervous system (by exercise and trauma)

A

Exercise
- recreational athletes show a shift towards the sympathetic nervous system
> if persistent this can cause high blood pressure and cardiovascular disease
- long term intensive athletic training causes a shift towards the parasympathetic nervous system

Trauma

  • PTSD causes a heightened sensitivity in the autonomic nervous system
  • tends to have persisting effects
24
Q

Brain facts

A
  • Brain is 2% of the body mass but receives 15% of the body’s blood supply and receives 20% of the body’s oxygen
  • no brain cell is further than 50 um (micrometers)
25
Meninges
Dura mater - tough and inflexible, divided into several layers Arachnoid mater - delicate, impermeable and avascular Pia mater - adheres closely to the brain - fuses with the lining of the ventricles to form structures that produce cerebrospinal fluid (CSF) The Peripheral Nervous System (PNS) has no pia mater, only 2 layers
26
CSF
Produced mainly by the Choroid Plexus, about 500ml daily
27
Homology
Structures can be considered as homologous if they have similar: - structure - connections - chemical signalling - gene expression - function
28
Three R's in animal research
All research should aim to: - Reduce the total number of animals used - Replace live animal testing with anything else where possible - Refinement (minimise suffering and distress to the animal)
29
Development of the body from 3 plates
Ectoderm - forms the skin and nervous system Mesoderm - forms bones and muscles Endoderm - forms the lining of internal organs
30
Development of the Ectoderm
- After 22 days from gestation, the neural plate forms the neural tube via Neurulation: > Neural plate folds at the Neural plate borders, forming a Neural Groove > When the Neural Folds fuse together, this groove becomes the Neural Tube and the folds form the Neural Crest + The Central Nervous System develops from the Neural Tube + The Peripheral Nervous System develops from the Neural Crest
31
Birth defects of nervous system maldevelopment (spina bifida)
Spina Bifida - the most common birth defect associated with live birth - occurs when the neural groove doesn't properly close up to form the neural groove, so there is a gap Severities: - Occulta > asymptomatic, normally a tuft of hair at the location - Meningocele > a sack containing spinal fluid at the location of non-fusing - Myelomeningocele (80-90% of cases) > a sack containing spinal cord, nerves and spinal fluid Symptoms: - depend on the severity and location - High on the spine could cause paralysis - Lower down could cause incontinence - Movement problems: > weakness or paralysis of lower limbs > deformed bones - Bladder and bowel problems > incontinence / UTI - Associated Hydrocephalus (enlarged head) [least common] > with many associated learning difficulties
32
Risk factors for Spina Bifida
- being white - being a girl - the mother has diabetes - the mother is obese - the mother has a folate (folic acid / vitamin B6) deficiency - certain medications (i.e. anti-seizure)
33
Differentiation of the Neural Tube
- firstly into 3 Primary Brain Vesicles > Forebrain, Midbrain, Hindbrain > Prosencephalon, Mesencephalon, Rhombencephalon - then these further differentiate: > Forebrain differentiates into 2 Telencephalic Vesicles, 2 Optic Vesicles and the Diencephalon > Midbrain differentiates into the Mesencephalon, which differentiates into the Tectum, Aqueduct and Tegmentum which form a layered tube (around the Cerebral Aqueduct) > Hindbrain differentiates into the Cerebellum, Pons and Medulla (also the 4th ventricle which is continuous with the aqueduct)