1: Schizophrenia Flashcards

1
Q

incidence of schizophrenia

A

1% worldwide

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2
Q

onset of schizophrenia

A

typically early in life: 15-25 y/o

  • during critical years of school, academic, and vocational development
  • Sx can hinder a person’s ability to meet their own goals
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3
Q

which parts of the mental status exam are grossly abnormal in schizophrenia?

A
  • thought process/form

- thought content

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4
Q

psychotic or positive Sx

A
  • hallucinations (disturbed perceptions)
  • delusions (disturbed thought content)
  • disorganization (disturbed thought formation)
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5
Q

negative Sx

A
  • restricted or inappropriate affect
  • avolition (lack of motivation)
  • alogia (paucity of speech)
  • inability to start and follow through with activities
  • lack of pleasure or interest in life
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6
Q

cognitive impairement Sx

A
  • difficulty prioritizing tasks or organizing thoughts
  • lack of insight (anosognosia)
  • problems with information processing and verbal memory
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7
Q

schizophrenia diagnosis criteria

A
  1. two or more of the following for a significant portion of one month:
    - delusions (fixed false beliefs)
    - hallucinations (usually auditory)
    - disorganized speech (tangential, incoherent, derailment)
    - grossly disorganized or catatonic behavior (agitation, posturing)
    - negative Sx (affective flattening, avolition, alogia)
  2. interpersonal or psychosocial dysfunction present
  3. continues signs of illness for at least 6 months with at least 1 month of active criterion A sx
  4. not due to another mental illness
  5. not due to substances or general medical condition
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8
Q

mental status abnormalities in attitude

A
  • suspicious
  • resistive
  • negativistic
  • guarded
  • hostile
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9
Q

mental status abnormalities in appearance

A
  • disheveled
  • unkempt
  • unshaven
  • no makeup
  • malodorous
  • mismatched and/or dirty clothing
  • impaired temp response
  • clothes inappropriate for weather
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10
Q

mental status abnormalities in behavior

A
  • awkward
  • decreased arm swing while walking
  • stereotypical movements
  • poor eye contact
  • decreased rate of speech
  • Parkinsonian gait and/or tremors (often med side effect)
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11
Q

mental status abnormalities in mood and affect

A
  • subjective: depressed, poorly described

- objective: FLAT, irritable, angry, hostile

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12
Q

mental status abnormalities in thought processes **

A
  • loose associations
  • disorganized
  • tangential
  • non-sequential
  • decreased spontaneity
  • unable to reach conversational goals
  • poverty of thought
  • thought blocking
  • alogia (paucity of speech)
  • neologisms
  • word salad
  • clang associations (putting together words based on alliteration or rhyming rather than meaning)
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13
Q

mental status abnormalities in thought content **

A
  • distortions of reality
  • psychotic
  • grandiose
  • paranoid delusions
  • delusions of thought broadcasting
  • thought insertion or thought control
  • ideas of reference from the TV or radio
  • bizarre delusions
  • auditory hallucinations (often complex)
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14
Q

mental status abnormalities in insight

A

-diminished capacity to understand that they are experiencing Sx of an illness and therefore need ongoing Tx

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15
Q

mental status abnormalities in judgment

A

-often poor as evidenced by lack of relationships, employment, inability to provide for basic needs of food and/or shelter

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16
Q

mental status abnormalities in intellect

A

-decreased working memory, future recall, decreased complex reasoning

17
Q

describe morbidity: the longer Sx are untreated or inadequately treated, the…

A
  • longer the time to remission
  • more residual Sx
  • worse long-term prognosis
18
Q

what physical changes occur in the brain in schizophrenia

A

accelerated brain gray matter loss

19
Q

timeline of schizophrenia

A
  • premorbid period: 0-18 y/o
  • prodromal period: 18-23y/o
  • onset/deterioration: 23-35 y/o
  • residual/stable: rest of life
20
Q

7 burdens of psychosis

A
  • early mortality
  • medical co-morbidities (huge amount of smoking)
  • suicide
  • substance abuse disorders
  • unemployment
  • homelessness
  • incarceration
21
Q

downward drift hypothesis

A

-individuals with schizophrenia enter into (or fail to rise out of) a lower socioeconomic group as a direct result of the illness –> there are a disproportionate number of schizophrenics in low socioeconomic groups

22
Q

two treatment models for schizophrenia

A
  1. medical model: to relieve Sx to cure disease

2. recovery model: to relieve Sx to improve fxn

23
Q

Tx (general)

A
  • medications
  • sometimes cognitive psychotherapies
  • case management
  • counseling/therapy
  • psychosocial rehabilitation
24
Q

goals of psychosocial rehabilitation

A
  • minimize stigma and integrate individuals into society

- impact either the env’t or the individual’s ability to deal with the env’t to facilitate improvement in Sx or distress

25
Q

7 first generation antipsychotics

A
  • thorazine (chlorpromazine)
  • mellaril (thioridazine)
  • prolixin (fluphenazine)
  • trilafon (perphenazine)
  • haldol (haloperidol)
  • moban (molindone)
  • loxitane (loxapine)
26
Q

9 second generation antipsychotics

A
  • clozaril (clozapine)
  • risperdal (risperidone)
  • zyprexa (olanzapine)
  • seroquel (quetiapine)
  • geodon (ziprasidone)
  • abilify (aripiprazole)
  • fanapt (iloperidone)
  • saphris (asenapine)
  • latuda (lurasidone)
27
Q

pros/cons of first gen vs. second gen antipsychotics

A

first gen:

  • dopamine antagonists
  • very effective
  • sedative properties
  • bad side effects w/ long term tx (parkinsonian Sx)

second gen:

  • more insulin resistance, development of DM, and obesity
  • alleviates the extrapyramidal effects found in first gen (due to serotonin effects)