1: Eating Disorders Flashcards

1
Q

epidemiology of eating disorders

A
  • anorexia: 1% of women
  • bulimia: 1-3% of women
  • binge-eating: 2% of women, 1% of men

female to male ratio 10:1 for anorexics

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2
Q

factors in the multifactorial pathogenesis

A
  • genetic: higher in monozygotic twins
  • psych: means of coping
  • biological: chemical changes occur w/ starvation
  • family: higher incidence in 1st degree relatives
  • env’t: higher in cultures that value thinness
  • social: teasing
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3
Q

7 risk factors for developing an eating disorders

A
  • female gender
  • early pubertal development
  • perfectionist
  • low self-esteem
  • sense of personal ineffectiveness
  • difficulties w/ communication, conflict resolution, and separation from family
  • drive to excel in sports
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4
Q

diagnostic criteria for anorexia

A
  • restriction of energy intake -> significantly low body weight
  • intense fear of gaining weight/becoming fat
  • disturbance in the way in which one’s body weight or shape is experiences/lack of recognition of the seriousness of the problem

weight usually below 85% of normal for age/gender

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5
Q

restricting subtype of anorexia

A

weight loss achieved by dieting, fasting, and/or excessive exercise

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6
Q

binge eating/purging subtype of anorexia

A

weight loss achieved by self-induced vomiting, misuse of laxatives/diuretics/enemas, diet pills, stimulants

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7
Q

anorexia levels of severity: mild, moderate, severe, extreme

A

mild: BMI 17-18.5kg/m2
moderate: BMI 16-16.99 kg/m2
severe: BMI 15-15.99 kg/m2
extreme: BMI

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8
Q

diagnostic criteria for bulimia

A
  • recurrent episodes of binge eating (eating in a discrete period a larger than normal amt or sense of lack of control over eating during episode)
  • recurrent inappropriate compensatory behaviors to prevent weight gain at least 1/week for 3 mo.
  • self eval is unduly influenced by body shape/weight
  • disturbance doesn’t occur during anorexic episodes
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9
Q

bulimia levels of severity: mild, moderate, severe, extreme

A

mild: 1-3 episodes/week
moderate: 4-7 episodes/week
severe: 8-13 episodes/week
extreme: 14 or more episodes/week

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10
Q

diagnostic criteria for binge-eating disorder

A
  • recurrent episodes of binge eating
  • episodes associated with 3 or more of the following:
    • eating too rapidly
    • eating until feeling uncomfortably full
    • eating large amts of food when not feeling hungry
    • eating alone b/c of embarrassment
    • feeling disgusted w/ oneself, depressed, or guilty after
  • marked distress regarding binge eating
  • at least 1/week for 3 mo
  • not associated with inappropriate compensatory behavior
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11
Q

binge-eating levels of severity: mild, moderate, severe, extreme

A

mild: 1-3 episodes/week
moderate: 4-7 episodes/week
severe: 8-13 episodes/week
extreme: 14 or more episodes/week

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12
Q

presenting symptoms of eating disorders

A
  • amenorrhea or menstrual irregularities
  • abdominal pain and bloating
  • cold intolerance
  • constipation
  • dizziness
  • dry skin
  • fatigue
  • GERD (from vomiting)
  • palpitations
  • syncope
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13
Q

physical findings in anorexia

A
  • acrocyanosis (blue fingers/toes)
  • bradycardia
  • emaciation
  • hypotension (especially orthostatic hypotension)
  • lanugo (fine hair)
  • cold extremities
  • hypothermia
  • atrophic breasts
  • edema of extremities
  • flat affect
  • alopecia (lose hair)
  • salivary gland enlargement (from starvation)
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14
Q

physical findings in bulimia

A
  • salivary gland enlargement (from vomiting), inflammation of parotid duct
  • calluses on knuckles (Russell’s sign)
  • mouth sores
  • dental enamel erosions
  • hypotension (especially orthostatic)
  • edema of extremities (more due to compensatory methods, like diuretics)
  • Mallory-Weiss tear (vomit forcefully and tear esophageal mucosa - usually present w/ bloody vomit)
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15
Q

lab abnormalities in anorexia

A
  • mild normochromic, normocytic anemia with moderate leukopenia
  • low blood sugar
  • elevated serum cholesterol
  • hyponatremia may be present from water loading
  • elevated liver enzymes from refeeding or apoptosis from starvation
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16
Q

lab abnormalities in bulimia

A
  • hypokalemia, hypochloremia with metabolic acidosis secondary to vomiting
  • hypokalemia with metabolic acidosis from laxative abuse
  • elevated serum amylase (from salivary gland)
17
Q

important questions to ask

A
  • weight: highest, lowest, desired?
  • feelings about current weight?
  • has anyone commented on weight?
  • type of diet? vegetarian common
  • rituals such as chewing certain number of times?
  • restricting foods they used to eat?
  • any purging of food?
  • any binging of food?
  • medications taken ?
  • menstrual history?
18
Q

suicide risk for eating disorders

A

-elevated in both anorexia and bulimia

19
Q

co-morbidities with bulimia

A
  • sexual promiscuity

- substance abuse

20
Q

lab tests for a suspected eating disorder

A
  • CBC and ESR
  • comprehensive metabolic profile (K+, Cl-)
  • magnesium
  • UA (specific gravity to see if water loaded)
  • EKG
  • thyroid function tests
  • bone densitometry (osteopenic)
21
Q

additional labs to consider based on H&P

A
  • urine B-hCG
  • serum amylase (to confirm purging)
  • FSH, LH, estradiol, testosterone, prolactin (for menorrheal issues)
  • stool for blood
  • GI endoscopy, CXR, head CT
  • PPD
22
Q

differential diagnosis options for weight loss (9)

A
  • anorexia
  • intentional dieting and exercise
  • CNS tumors (hypothalamic, pituitary)
  • endocrine disorders (hyperthyroid, T1DM, addison’s)
  • GI disorders (IBS)
  • chronic infection (AIDS, TB)
  • CT disorders (SLE)
  • malignancy (lymphoma)
  • other psych disorders (MDD)
23
Q

4 principles of successful care of eating disorders

A
  1. early restoration of normal state
  2. establishment of trust
  3. involvement of family in treatment
  4. team approach - medical, nutritional, psychological
24
Q

levels of care for eating disorders

A

-hospital inpatient
-outpatient
-partial hospitalization (12 h for 5d/week)
-intensive outpatient program (IOP) - 8h for 3d/week
-residential - one or two month stay
-regular visits with health care provider, psychotherapist
and nutritionist while maintaining activities of daily life

25
Q

medical criteria for hospitalization

A

severe metabolic disturbances

-HR

26
Q

psychiatric criteria for hospitalization

A
  • severe depression
  • psychosis
  • family crises
  • failure to comply with eating disorder contract
27
Q

what drug is approved for bulimia treatment?

A

fluoxetine/prozac

-in higher doses than for depression -> 60 mg/day

28
Q

pharm treatment for anorexia

A
  • olanzapine/zyprexa may be helpful: promotes weight gain, decreases obsessive thinking
  • avoid meds that prolong QT interval
29
Q

what drug is contraindicated in treating eating disorders and why?

A

buproprion/wellbutrin/zyban - b/c increased incidence of seizures

30
Q

definition of refeeding syndrome

A

clinical complications that occur as a result of fluid and electrolyte shifts during nutritional rehab of malnourished patients

  • stores of phosphate depleted during AN/starvation
  • feeding -> release insulin -> cell uptake of phosphate, K+, Mg2+ and increase production of ATP
  • lack of phosphorylated intermediates causes tissue hypoxia and resultant myocardial dysfunction and resp failure
31
Q

clinical components of refeeding syndrome (6)

A
  • hypophosphatemia
  • hypokalemia
  • hypomagnesemia
  • vitamin and trace mineral deficiencies
  • volume overload
  • edema