1. Psychotic disorders Flashcards
Command hallucinations
auditory hallucinations that directly tell the pt to perform certain acts
Delusion vs. Illusion vs. hallucination
Delusion = false belief that cannot be altered Illusion = misinterpretation of an EXISTING sensory stimulus (such as mistaking a shadow for a cat) Hallucinations = sensory perception WITHOUT an actual external stimulus
Most commonly exhibited hallucination exhibited by schiz pts?
Auditory
DDx of psychosis secondary to general medical condition (4 categories)
- CNS disease (ex. MS, neoplasm, Alzheimer, Parkinson, Huntington chorea, tertiary syphilis, temporal lobe epilepsy, encephalitis, prion disease, neurosarcoidosis, AIDS)
- Endocrinopathies (Addison/Cushing disease, hyper/hypothyroidism, hyper/hypocalcemia, hypopituitarism)
- Nutritional/vit deficiency states (B12, folate, niacin)
- Other (SLE, temporal arteritis, porphyria)
What is delirium?
Acute confusional state
Work-up needed when pt with suspected schiz comes in
TSH, rapid plasma reagin (RPR), brain imaging, urine/serum drug screening
5 A’s of schiz (negative symptoms)
- Anhedonia
- Affect (flat)
- Alogia (poverty of speech)
- Avolition (apathy)
- Attention (poor)
Ecolalia vs. Echopraxia
Ecolalia = repeats words or phrases Echopraxia = mimics behavior (PRActices behavior)
Time differences b/w psychotic disorder, schizophreniform disorder, schizophrenia
Brief psychotic disorder = < 1month
Schizophreniform = 1-6 months
Schizophrenia = > 6months
Schizophrenics psych exam findings
- disheveled appearance
- flattened affect
- disorganized thought process
- intact memory and orientation!!
- auditory hallucinations
- paranoid delusions
- ideas of reference
- concrete understanding of similarities/proverbs
- lack insight into their disease
Lifetime prevalence of schiz?
1% over lifetime
Difference in men and women affected by schiz
equally affected by diff. presentations and outcomes
- men = present around 20 yo; more negative symptoms, more impaired social functioning
- women = present around 30 yo
Genetic predisposition of schiz
- 50% concordance among monozygotic twins
- 40% risk if both parents have sciz
- 12% risk if one 1st degree relative is affected
Comorbidity with schiz?
substance abuse
- alcohol (30-50%)
- cannabis (15-20%)
- cocaine (5-10%)
Downward drift hypothesis?
ppl suffering from schiz are unable to function well in society, thus enter lower socioeconomic groups
What is akathisia?
Unpleasant, subjective sense of restlessness (often manifested by the inability to sit still)
Bad prognostic factors of schiz?
early onset, poor social support, negative symptoms, family hx, gradual onset, male sex, many relapses, poor premorbid functioning (social isolation etc), comorbid substance abuse
What is neologism?
use of words that have meaning only to the person who uses them
Schizoaffective disorder vs. mood disorder w/ psychotic features
- Schizoaffective = delusions or hallucinations for 2 wks in ABSENCE of mood disorder
How much % of pts w/ schizoaffective will progress to schizophrenia?
60-80%
What population of ppl are delusional disorder more prevalent in? (3)
- older pts (>40yo)
- immigrants
- hearing impaired
Criteria for delusional disorder
- nonbizarre, fixed delusions for at least 1 month
- does NOT meet criteria for schiz
- functioning in life NOT significantly impaired
Treatment for delusional disorder
- note: very difficult to treat
- psychotherapy may be helpful
- anti-psychotics often ineffective (but a course should be tried)
What is shared psychotic disorder?
pt develops the same delusional symptoms as someone he/she is in a close relationship with (family members)
Treatment of shared psychotic disorder?
20-40% will recover upon removal from inducing person
- usually inducing person has an underlying psychotic disorder
- psychotherapy and anti-psychotic meds if symptoms does not improve in 1-2 wks after separation
Prognosis from best to worst of psychotic disorders (5) ex. schizophreniform disorder, schizoaffective, mood disorder
mood disorder > brief psychotic disorder > schizoaffective disorder > schizophreniform disorder > schizophrenia
What is schizotypal vs. schizoid?
- Both are personality disorders
- schizotypal = paranoid, odd or magical beliefs, eccentric, lack of friends, social anxiety. Criteria for true psychosis not met
- schizoid = withdrawn, lack of enjoyment from social interactions, emotionally restricted