1: Nucleosides and nucleotides Flashcards
1
Q
What are nucleosides made of?
A
Base and sugar
2
Q
What are nucleotides made of? And what are they?
A
Base, sugar and nucleotide
A phosphorylated nucleoside
3
Q
Two types of nucleotides
A
Purines(AG) and pyrimidines(CTU)
4
Q
How can purines be synthesized?
A
Synthesized de novo or salvaged from cells and food
5
Q
What is produced from the breakdown of purines?
A
Uric acid
6
Q
2 diseases caused by purine metabolism
A
Adenosine deaminase deficiency:
inherited immune deficiency disease, low levels of T and B lymphocytes
Gout:
excess uric acid in tissues and joints crystallises
7
Q
Why are nucleotides important?
A
-makes DNA and RNA
-anti-viral/ anti-cancer drugs may interfere with nucleotide breakdown
-plays central role in metabolism(sources of chem E, cofactors of enzyme reactions)
