1 - Neurology History, Examination and Localisation Flashcards

1
Q

If a patient presents with the following neurological symptoms, what are some important further questions to ask?

  • Headache
  • Muscle weakness
  • Visual disturbance
  • Dizziness
A

ALWAYS TRY TO GET COLLATERAL HISTORY

- Headache: different to usual? acute/chronic? speed of onset? uni/bilateral? aura? any meningism? worse on waking? any decrease in consciousness? thunderclap?

- Muscle weakness: speed of onset? groups of muscles affected? sensory loss? sphincter disturbance? loss of balance?

- Visual disturbance: blurring? diplopia? speed of onset? photophobia? vision loss? preceding symptoms? pain in the eye?

- Dizziness: vertigo? hearing loss? tinnitus? LOC? tinnitus?

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2
Q

If a patient presents with the following neurological symptoms, what are some important further questions to ask?

  • Speech disturbance
  • Dysphagia
  • Fits/Faints/Funny turns/Involuntary movements
  • Abnormal sensations
  • Tremor
A

- Speech disturbance: difficulty in expression, comprehension or articulation?

- Dysphagia: solids and/or liquids? intermittent or constant? difficulty in coordination? odonyphagia?

- Fits/Faints/Funny turns/Involuntary movements: frequency? duration? mode of onset? incontinence? tongue biting? aura? LOC? residual weakness/confusion? FHx?

- Abnormal sensations: numbness? pins and needles? pain? distribution? speed of onset? weakness?

- Tremor: rapid or slow? present at rest? worst on movement? taking B agonists? any thyroid issues? FHx?

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3
Q

If there is a doubt about a patients cognitive state, what test can you do?

A

AMTS - Any score of 6 or less suggests cognitive decline

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4
Q

What are some patients that you cannot use AMTS score in?

A
  • Deaf
  • Dysphasic
  • Depressed
  • Uncooperative
  • English not first language
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5
Q

What questions in the PMHx, DHx and SHx can you ask a patient with a neurological presentation?

A

PMHx: meningitis? head/spine trauma? seizures? previous operations? risk factors for vascular disease e.g smoking, AF? recent travel? pregnant?

DHx: anticonvulsants? antipsychotics? antidepressants? psychotropic drugs e.g ecstasy? any meds with neurological side effects e.g peripheral neuropathy in isoniazid

SHx: what ADLs can’t they do? FHx of neuro/psychiatric disease? syphillis?

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6
Q

What is cramp and what are some causes of this?

A

Painful muscle spasm

  • Salt depletion
  • Muscle ischaemia (claudication, DM)
  • Myopathy
  • Dystonia
  • MND (forearms)
  • Drugs e.g Diuretics, Domperidone, Salbutamol
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7
Q

What are some causes of paraesthesia? (‘pins and needles’, numbness, tingling)

A

- Metabolic: decreased Ca, increased PaCO2

- Vascular: arterial emboli, DVT, high plasma viscosity

- Infection: lyme, rabies

- Cord: MS, myelitis, HIV, B12, lumbar fracture

- Paroxysmal: migraine, epilepsy

- Peripheral neuropathy: glove and stocking

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8
Q

What is a tremor and what are some of the different kinds of tremor?

A

Rhythmic oscillations of limbs, trunk, head or tongue

Resting: Occurs at rest, gravity dependent, Parkinsons (pill rolling slow tremor 3-5Hz)

Postural: Worst if arms outstretched, rapid 8-12Hz. Can be exagerrated physiological tremor (anxiety, hyperthyroidism, alcohol), Brain damage (syphillis, Wilson’s) or Benign Essential tremor

Intention: Worst on movement, in cerebellar disease with past pointing and dysdiadochokinesis

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9
Q

What is a Benign Essential Tremor , how can it be managed and how can you distinguish it from a PD tremor?

A
  • Usually familial (autosomal dominant) of the arms or head presenting at any age
  • May have cogwheeling but no bradykinesia
  • Suppressed by alcohol

- Propanolol can help

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10
Q

What are some neurological causes of facial pain?

A
  • Trigeminal neuralgia
  • Migraine
  • Post-herpetic neuralgia
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11
Q

How do you do a cerebellar examination?

https://geekymedics.com/cerebellar-examination-osce-guide/

A

- Introduction

- Gait/Tandem Gait

- Romberg’s (sensory ataxia)

- Speech (British Constitutuion, Baby Hippopotamus)

- Nystagmus

- Finger Nose (past pointing)

- Tone (hypo)

- Dysdiadochokinesis

- Reflex (hypo)

- Heel shin test

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12
Q

What are some causes of cerebellar disease?

A
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13
Q

How do you do a cranial nerve exam?

https: //oscestop.com/Cranial%20Nerves.pdf
https: //geekymedics.com/wp-content/uploads/2020/10/OSCE-Checklist-Cranial-Nerve-Examination.pdf

A

Intro: any pain?

1: Changes in smell?

2: AFRO Assess pupil size, Pupil reflexes, Swinging Light, Accomodation,Visual Acuity (wear glasses), Visual fields, Fundoscopy

3, 4, 6: Any double vision or nystagmus on eye movements? Cover test

5: Cotton wool and neurotip

7: Muscles of mastication, jaw jerk reflex, corneal reflex

8: Gross hearing, Weber’s + Rinne’s with 512Hz

9, 10: Say ahh, Gag reflex, Cough

12: Stick tongue out and move side to side, tongue strength

11: Shrug shoulders against resistance

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14
Q

If someone has a headache how can you rule out meningitis?

A

If they can shake their head side to side there is no meningism

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15
Q

What are some causes of cranial nerve palsies? (example for each CN)

A

IMPORTANT CARD PLEASE SIT AND REMEMBER!

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16
Q

What are the dermatomes of the head, upper limb, lower limb?

A

Head:

Trigeminal on face

C2/C3 on back

Upper limb:

C4 - shoulder

C5-T1 - arms

Lower Limb:

L1 to S2 - Legs

S4/S5 - perianal area

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17
Q

What nerve root is the bladder and rectum motor supply?

A

S4

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18
Q

Where does the cervical plexus innervate?

A

Diaphragm, shoulders and neck

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19
Q

What are the phases of the gait cycle?

A
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20
Q

What are some causes of the following gaits?

  • Hemiplegic
  • Diplegic/Scissoring
  • Parkinsonian’s
  • Ataxic
A

Hemiplegic:

  • CNS lesion leading to unilateral weakness and spasticity. UMN lesion. Spastic flexion of upper limb and spastic extension of lower limb

- Causes: stroke, SOL, trauma, MS

Diplegic: (usually UMN)

- Cord: Prolapsed intervertebral disc, Spinal infarct, Syringomyelia

- Bilateral brain lesion: Cerebral palsy, MS

- Bilateral brain infarcts

- Midline tumour

- Motor neuron disease: associated with LMN findings

Parkinsonian’s:

  • Vascular Parkinson’s disease, Dementia with Lewy bodies, Drug-induced Parkinsonism (e.g. antipsychotics, antiemetics)

Ataxic:

- Midline cerebellar disease: alcoholic cerebellar degeneration

- Vestibular disease: labrynthitis

- Loss of proprioception: sensory ataxia

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21
Q

What are some causes of the following gaits?

  • Neuropathic/High-steppage
  • Myopathic/Waddling
  • Choreiform/Hyperkinetic
  • Antalgic
A

Neuropathic/High-steppage

Weakness of the dorsiflexors in the distal lower limb

Causes: Isolated common peroneal nerve palsy (e.g. trauma), L5 radiculopathy (e.g. disc prolapse), Generalized polyneuropathy involving multiple nerves (e.g. diabetic neuropathy, motor neurone disease, Charcot-Marie Tooth disease)

Myopathic/Waddling

Weakness of hip abducters so pelvis tilts downwards towards unsupported side during swing phase

Causes: muscular dystrophies, thyroid issues, polymyalgia rheumatica, polymyositis, dermatomyositis

Choreiform/Hyperkinetic

Gait with involuntary movements e.g oro-facial dyskinesia (grimacing or lip-smacking), choreic movements of the upper and lower limbs

Causes: Huntington’s, Cerebral Palsy, Parkinson’s medication

Antalgic

Pain

Causes: OA, lower limb fracture, sciatica

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22
Q

What are the features of a Parkinsonian gait?

A

Also will have tremor, rigidity, bradykinesia

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23
Q

How can you tell the difference between cerebellar, sensory and vestibular ataxia and what are some causes of each of these?

IMPORTANT CARD

A

Cerebellar ataxia:

  • Nystagmus
  • Ataxic dysarthria
  • Dysmetria
  • Intention tremor
  • Dysdiadokokinesia

Sensory ataxia:

  • Positive Romberg’s sign
  • Impaired proprioception
  • Impaired vibration sensation
  • Absence of other cerebellar signs (e.g. dysmetria, nystagmus, dysarthria)

Vestibular ataxia:

  • Vertigo
  • Nausea
  • Vomiting
24
Q

What GCS do you need to be worried about a patient’s airway?

25
How do you calculate GCS? IMPORTANT CARD
Evaluates the level of consciousness of a patient If cannot do one of the sections e.g oedema round eyes, paralysed, then write NOT TESTABLE (NT) 3 is lowest, 15 is highest. Always record in notes and say what they score for each
26
What is decorticate and decebrate positioning and what do they both indicate?
**_Decorticate_** - Abnormal flexion - Adduction of the arm, internal rotation of the shoulder, pronation of the forearm and wrist flexion - Indicates ***damage to cerebral hemispheres, internal capsule and thalamus*** **_Decebrate_** - Abnormal extension - Head is extended, arms and legs also extended and internally rotated. Patient appears rigid with teeth clenched ***- Indicates damage to brainstem*** ***- Progression from decorticate to decebrate suggests uncal or tonsillar herniation***
27
What are the different points on the MRC power scale?
3 Gravity (Rhymes) Remember Neil laying on side for 2
28
How do you do a lower limb neurological examination? https://oscestop.com/Lower%20limb%20neurological%20exam.pdf
TOPCARS and SWIFT **- Introduce:** any pain, exposure **- Inspection:** gait, tremor, wasting, SWIFT **- Tone:** leg roll and clonus **- Power:** isolate/stabilise joint **- Coordination:** heel to shin, toe tap **- Reflexes:** knee, ankle, plantar **- Sensation and Proprioception:** cotton wool, neurotip, vibration (BIGGER ONE - 128Hz), joint position
29
How do you do an upper limb neurological exam? https://oscestop.com/Upper%20limb%20neurological%20exam.pdf
**- Introduction:** any pain? exposure **- SWIFT** **- Pronator drift** **- Tone** **- Power** **- Coordination:** dysdiadochokinesis, finger nose **- Reflexes**: biceps, triceps, supinator **- Sensation and Proprioception:** bigger tuning fork!! make sure they close their eyes!!!! did it feel the same both sides?
30
How do you do a Parkinson's focused neurological examination? (use link more) https://oscestop.com/Parkinsons\_exam.pdf
**- Inspection:** gait, resting tremor with eyes closed and counting back from 20 (asymmetrical resting pill rolling, begins distally, reduced with finger to nose testing), intention tremor **_Work downwards:_** **- Face:** Hypomimia, Glabella Tap (Myerson's sign), Hypophonic speech **- Upper limbs**: Tone (lead pipe or cogwheel tremor on increased tone) and Bradykinesia - **Lower limbs:** toe tap **- Others:** micrographia (write sentence, draw spiral), undo buttons on shirt
31
What are the features of a resting tremor in Parkinson's?
Resting tremors occur **when a body part is at complete rest against gravity** and **cease during active movement**
32
What is a HINTS examination?
**Head Impulse, Nystagmus, Test of Skew** examination Way to assess a patient to see if **central or peripheral vertigo**
33
How do you perform a HINTS examination?
34
How do you perform a comprehensive neurological examination?
1. Mental Status 2. Cranial Nerves 3. Motor Function 4. Reflexes 5. sENSATION
35
How do you perform a neurological examination on a patient with an altered level of consciousness (either unconscious or semi-conscious)?
1. Level of consciousness (GCS) 2. Pupil responses 3. Fundoscopy 4. Brain stem reflexes 5. Deep tendon reflexes 6. Plantar response
36
What are some cerebellar signs?
D - Dysdiadochokinesis A - Ataxic gait N - Nystagmus I - Intention tremor S - Slurred/Staccato speech H - Hypotonia and reduced power
37
How can you localise a lesion when thinking of the pattern of motor loss?
- Need to think cortex, corona radiata, internal capsule, brainstem, cord, roots, peripheral nerves, neuromuscular junction, muscles - Is it UMN or LMN? - Is it unilateral or bilateral?
38
What are the different motor systems in the CNS?
**_Corticospinal tracts (pyramidal)_** - Skilled, intricate, strong and organised movements - Defectiveness: loss of skilled voluntary movement, spasticity and reflex changes. Such as hemiparesis, hemiplegia or paraparesis **_Extrapyramidal_** - Fast, fluid movements that the corticospinal system has generated - Doesn't directly innervate motor neurones - Defectiveness: bradykinesia, rigidity, tremor, chorea **_Cerebelllum_** - Co-ordinating smooth and learned movement initiated by the pyradimal system and in posture and balance control - Defectiveness: ataxia, past pointing, action tremor and incoordination
39
If there is a cord lesion do you expect LMN signs or UMN signs?
- At the level of the lesion LMN - Below level of lesion UMN
40
If there is a cranial nerve palsy contralateral to a hemiparesis, where does this localise the lesion to?
The brainstem on the side of the cranial nerve palsy
41
What are the different sensory pathways in the CNS? (make sure you can draw diagrams)
**Peripheral nerves:** sensation from dorsal roots to cord **Dorsal columns:** - Vibration, joint position, light touch and point discrimination - Decussate in medulla passing to the thalamus **Spinothalamic tracts:** - Pain and temperature - Decussate in the cord and pass in the spinothalamic tracts to the thalamus and reticular formation **Sensory cortex:** Fibres from thalamus pass to parietal region sensory cortex and motor cortex
42
What are signs of an UMN lesion?
- **Tone**: Hypertonia and Clonus **- Reflexes:** Hyperreflexia and Babinski **- Atrophy:** Late and due to disuse **- Spasticity** **- Hoffman's reflex positive** **- Clasp knife rigidity** UMN MAY APPEAR AS LMN FOR FIRST FEW HOURS AFTER INJURY (ACUTE FLACCID PARALYSIS)
43
What are signs of a LMN lesion?
**- Hyporeflexia** **- Hypotonia/Flaccid** **- Absent reflexes** **- Fasiculations** **- Severe dennervation atropy**
44
How can you tell the difference between a LMN lesion due to muscle disease and due to peripheral neruropathy?
**Muscle disease:** will be bilateral and no sensory loss **Peripheral neuropathy:** sensory loss and reflexes lost faster
45
What are negative and positive extra-pyramidal symptoms?
**Negative:** bradykinesia, loss of postural reflexes **Positive:** tremor, rigidity, involuntary movements e.g chorea, hemiballismus
46
What is the blood supply to the brain? (memorise image)
**Circle of Willis** - Anastomosis of vertebral artery and ICAs - Anterior and Middle cerebral arteries come from ICA. Posterior cerebral artery comes from vertebral
47
Which cerebral arteries supply which lobes of the brain and therefore what would be the symptoms if there was an occlusion in one of these arteries?
**_ACA:_** Weak numb contralateral leg +/- same with arm. Face sparing **_MCA:_** Contralateral hemiparesis, hemisensory loss, contralateral homonymous hemianopia (optic radiations involved), dysphasia, visuo-spatial disturbance **_PCA:_** Supplies occipital so contralateral homonymous hemianopia with macular sparing
48
What are some examples of neurotransmitters?
**- Amino acids:** Glutamate and Aspartate are excitatory, GABA is inhibitory ## Footnote **- Dopamine** **- Serotonin** **- Adrenaline and Noradrenaline** **- Acetylcholine**
49
What are some examples of drugs that increase and decrease neurotransmitter activity?
50
What is a pyramidal pattern of muscle weakness?
In UMN lesions - Extensors weaker than flexors in arms - Flexors weaker than extensors in legs STROKE - HEMIPARESIS
51
What is the difference between spasticity and rigidity?
Both in **hypertonia**, think about **velocity** **- Spasticity (resistance more in one movement):** stroke, MND **- Rigidity (resistance same for all movement, not velocity dependent):** PD, neuroleptic syndrome
52
What is the pattern of sensory loss in the following: - Mononeuropathy - Peripheral neuropathy - Radiculopathy - Spinal cord damage - Thalmic lesions e.g stroke - Myopathy
**- Mononeuropathy:** Area supplied by one nerve **- Peripheral neuropathy:** Symmetrical glove and stocking **- Radiculopathy:** Dermatomal **- Spinal cord damage:** At and below level in dermatomal pattern **- Thalmic lesions e.g stroke:** Contralateral loss **- Myopathy:** No loss of sensory, just motor
53
How do you do an upper limb neurological examination?
54
How do you do a lower limb neurological examination?
55
How do you do a cranial nerve examination?