1. Drug Interactions

Question 1

Ketoconazole + _____

Answer 1

PPI/H2 Antagonist - reduced absorption

Question 2

Digoxin + Rifampicin

Answer 2

reduced digoxin levels

Question 3

Digoxin + quinidine

Answer 3

increased risk of toxicity

Question 4

Gentamicin + furosemide

Answer 4

risk of gent toxicity

Question 5

Statin + Macrolides

Answer 5

Erythromycin?
increased risk of rhabdomyolysis, myalgia, dark urine, weakness, macrolides inhibit P450 enzymes, decreasing statin elimination

Question 6

Metformin + cimetidine

Answer 6

competition for renal tubular clearance

Question 7

Digoxin + amiodarone

Answer 7

competition for renal tubular clearance

Question 8

Lithium + thiazide

Answer 8

thiazide decreases lithium clearance

Question 9

Methotrexate + Aspirin

Answer 9

Aspirin decreases methotrexate clearance

Question 10

ACE Inhibitors + Potassium-sparing diuretics

Answer 10

hyperkalaemia

Question 11

Metformin + ACE Inhibitors

Answer 11

hypoglycaemia

Question 12

Amiodarone + Quinolones

Answer 12

Both blocking cardiac K+ channels and cause Prolonged QT Syndrome

Question 13

Beta Blockers + Salbutamol

Answer 13

Oposing effects

Question 14

Opioids + Naloxone

Answer 14

Opposing effects