1- Cardiovascular diseases Flashcards
What are the 3 types of microbial infections of endocardium/heart valves?
- Bacterial infections
- Fungal infections
- Viral infections
How are the infections of endocarditis classified?
1.) by organisms causing the infection
2.) Type of valves being infected
3.) The source of infection
What are the risk factors associated with these infections?
1.) Damaged heart valves
2.) Artificial heart valves
3.) Congenital heart defects
4.) History of endocarditis
5.) History of IV drug use
What are the clinical presentations of infective endocarditis?
1.) Fever
2.) Heart murmur
3.) Extremities
What is the clinical result from the immune system detecting & trying to combat pathogens?
Fever
What is the clinical presentation that results in disruption in blood flow in the heart, valves not completely closing, & backflow of blood (turbulence which can auscultated)
Heart murmur
What are the 4 types of clinical presentations underlying extremities?
1.) Osler nodes
2.) Janeway lesiokns
3.) Spinter hemorrhages
4.) Nail clubbing
What are raised red lesions on hands & feet know as?
Osler nodes
What are flat papules on palms of hands or soles of feet recognized as?
Janeway lesions
What are streaks of blood under fingernails known as?
Splinter hemorrhages
What are enlargement of finger tips known as?
Nail clubbing
What are the oral presentations of infective endocarditis?
Petechiae (found on the palatal & mucosa)
What are the dental management steps for infective endocarditis?
1.) Bleeding & bacteremia
2.) Antibiotic prophylaxis
3.) Treatment planning
What can dental hygiene treatment induce in people with infective endocarditis?
They can result in transient bacteremia, further increasing the risk factors for patients with infective endocarditis
What is the hypothesis of treating bacteremia in infective endocarditis?
That antibiotic prophylaxis will reduce bacteremia & therefore decrease the risk of infective endocarditis
What are the recommended doses & instructions of antibiotic prophylaxis in people with infective endocarditis?
1.) Single dose 30-60 minutes prior to the appointment
2.) May be given up to 2 hr after procedure if not given prior beforehand
What are the treatment planning recommendations for infective endocarditis?
1.) Antibiotic prophylaxis
2.) Emphasis on optimized oral health to reduce bacterial burden
3.) Appointment scheduling:
- appts > 6hrs may need additional prophylactic antibiotics
- allow at least 10 days between sessions (clearance of antibiotic resistant organisms from oral cavity)
What are the common ways the bacteria can enter in the body to induce a potential case of infective endocarditis?
Via the mouth or intravenously
What will occur if the bacteria adheres to an area that is injured or inflamed?
The bacteria will persist in this particular area through adherence & will eventually proliferate & disseminate to leave to other areas of the body
What similiar role does dissemination have when it leaves the area proliferation to transport itself to other areas of the body?
It can induce a blood clotting role in other areas of the body.
when would we recommend antibiotic prophylaxis for individuals with infective endocarditis?
When these individuals have:
1.) Prosthetic cardiac valve
2.) Previous infective endocarditis
3.) Congenital heart disease
What type of dental procedures would we require a patient to have taken an antibiotic prophylaxis prior to treatment?
Dental procedures involving manipulation of gingival tissue or the periapical region of teeth or perforation of the oral mucosa
Are dental procedures such as routine anesthetics, dental radiographs, placement of removal prosthondontic/orthodontic appliances call for a need of an antibiotic prophylaxis?
No they do not require an antibiotic prophylaxis as they do not involve manipulation of the gingival tissue or periapical region of teeth/perforstion of the oral mucosa
How much amoxicillin will be given ORALLY to an ADULT 30-60 minutes before a procedures
2g (2 grams)
How much amoxicillin will be given ORALLY to a CHILD 30 - 60 minutes before a procedure?
50mg/kg
If the patient cannot take the antibiotic via oral administration, what would we be the other alternative?
Via intravenous or intramuscular administration.
What are the agents used if oral administration cannot be given?
Ampicillin + Cefazolin
Ceftriazone
How much Cefazolin/Ampicillin IV/IM is given to an ADULT 30-60 mins prior to an appointment?
2g IM or IV
How much Ceftriaxone IV/IM is given to an ADULT 30-60 mins prior to an appointment?
1g IM or IV
How much Amipicillin/ Cefazoline or Ceftriazone IV/IM is given to a CHILD 30-60 mins prior to an appointment?
50mg/kg IM or IV
What are the alternative agents given to a patient when they are allergic to penicillins or ampicillins, but can be administered ORALLY?
Cephalexin, clindamycin & clarithormycin
What are the alternative agents given to a patient when they are allergic to penicillins or ampicillin, and must be administered INTRAVENOUSLY or INTRAMUSCULARLY?
Cefazolin, ceftriaxone & clindamycin
How much cephalexin ORALLy can be given to an adult 30-60mins prior to an appointment?
2g (2 grams) / 50mg/kg
How much clindamycin ORALLY & IV/IM can be given to an adult 30-60 mins prior to an appointment?
600 mg / 20mg/kg
how much clarithromycin ORALLY & IV/IM can be given to an adult 30-60 mins prior to an appt?
500mg / 15mg/kg
How much cefazoline/ceftriaxone can be given to an ADULT & CHILD via IM/IV?
1g for an adult / 50mg/kg for a child
How much clinadymycin can be given to an ADULT & CHILD via IM/IV?
600 mg for an adult / 20mg/kg IM or IV