1 Basic Concepts Flashcards
What do the words cranial and caudal mean?
- Cranial= towards the head
- Caudal= towards the tail
Which of the following is the saggital, coronal and transverse plane?
What is the embryological developmental origin of Bone, Connective Tissue and Skeletal Muscle?
Mesoderm of trilaminar disc
What are the functions of bone? (6)
- Support- framework
- Protection- eg skull protects brain
- Metabolic- homeostasis of calcium and phosphate
- Storage- calcium and phosphate, IGFs (insulin like growth factors)
- Movement- attachments for muscles
- Haematopoiesis-cavities of bone
Describe the general structure of skeletal muscle.
Striated muscle
Voluntary control
What are the functions of skeletal muscle? (6)
- Locomotion
- Posture-equilibrium
- Metabolic (see MEH)
- Venous return
- Heat production- shivering
- Continence (pelvic floor)
Name the 4 main types of connective tissue that have important roles in the MSK system.
- Tendons- connect muscle to bone
- Ligaments- connect bone to bone (supportive+prevent excessive movement)
- Fascia- sheets of CT-envelopp groups of muscles, divide compartments, protective
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Cartilage
- Hyaline- v smooth, helps frictionless motion
- Fibrocartilage - higher collagen than hyaline, shock absorption, increase bony congruity (make up menisci of knee)
What is the purpose of synovial membrane and what is it made up of?
= in joints, bursae, tendon sheaths
= produce synovial fluid - LUBRICATES joints
What is hydroxyapatite and what does it do?
=Calcium phosphate
=Mineralises extracellular matrix in bone
What is the major fibre type found in bone?
Collagen
Which part of bone gives it its:
- Compressive strength
- Tensile strength
- Compressive strength= calcium phosphate
- Tensile strength=collagen
What do osteoblasts do?
Synthesise new bone, deposit osteoid
What is osteoid?
Matrix protein of bone: collagen, osteocalcin, osteopontin
Fill in the missing labels:
Describe osteoclast structure.
Multinucleate cell
Formed- fusion of progenitor cells (from macrophage lineage)
What is the function of osteoclasts?
Secrete acidic chemicals- dissolve bone matrix- forms pit- cortical bone
Releases absorbed minerals- blood
Once an osteocyte is formed it is trapped in lacunae. How does it communicate with other osteocytes?
Filipodia (projections)
Whats the difference between the axial and appendicular skeleton?
- Axial= longitudinal axis
- Appendicular= bones of upper and lower limbs