1 Antibiotics - more infomation

Question 1

2 organisms often affected by ESBL?

Answer 1

e. coli & klebciella

Question 2

3 broad spec beta lactamases in order of spectrum:

Answer 2

WIDEST SPECTRUM
Meropenem
Tazocin
Coamox
NARROWEST SPECTRUM

Question 3

All betalactamases have good gram ______ activity. But the narrower ones ONLY have this.

Answer 3

Positive

Question 4

What is the only oral agent for gram negative infections?

Answer 4

Ciprofloxicin
( also levofloxicin - but this is slightly more gram +ve)

Other are IV: Amik, Gent, Moxifloxicin, Collistin

Question 5

In what way is vancomycin better than teicoplanin

Answer 5

It can penetrate where teic cannot

Question 6

What is the role of gent in endocarditis

Answer 6

potentiate the ben pen. As it brings down the level of ben pen you need. If not you would need more than the max dose to penetrate

Question 7

Why don’t you use linezolid and meropenem?

Answer 7

Mero is broad spec and linezolid is broad spec only gram positive.

So they are both treating the same thing.

Question 8

Previous antibiotic use in the last ____ days is a risk factor for HAP

Answer 8

90

Question 9

Amikacin is not used for HAP because

Answer 9

awful lung penetration

Question 10

What is the role of gent in UTI treatment?

Answer 10

Gram -ve cover until MCS comes back. That is why its a stat dose.

Question 11

4 causes of c diff

Answer 11

Clindamycin
Quinilones (levofloxacin, ciprofloxacin)
Penicillins (broad spec)
Carbopenems