1

Question 1

activation of a1 receptors leads to what

Answer 1

activation of muscle contraction

• SM = vasoconstriction
• cardiac m = increased contractile force on heart

Question 2

exception of a1 normal effect location

Answer 2

in the gut

• causes relaxation due to hyperpolarization of Ca2+/K+ channel
• K+ out

Question 3

activation of a2 receptors leads to what

Answer 3

vascular smooth muscle contraction
decreased insulin secretion
decreased release of NE (presynaptic a2 receptors)

Question 4

potency in order of agonists in a-receptors

Answer 4

epi>norep»isoproterenol

Question 5

what are a1 receptors preferentially activated by

Answer 5

phenylephrine

Question 6

what are a2 receptors preferentially activated by?

Answer 6

clonidine

Question 7

activation of the B receptors leads to what

Answer 7

activation of adenylyl cyclase and increased concentrations of cAMP through Gs proteins

Question 8

B1 receptors are mainly found in ___

-activation leads to what

Answer 8

myocardium

-activation = increased force and rate of heart contraction and AV nodal conduction velocity

Question 9

B2 receptors are found on _____ and most other sites

-activation leads to what

Answer 9

smooth muscle

-activation causes vascular, bronchial, genitourinary, and GI SM to relax

Question 10

B1 receptors preferentially respond to agonist ____

Answer 10

dobutamine

Question 11

B2 receptors preferentially respond to the agonist ___

Answer 11

terbutaline

Question 12

B3 receptors are found only in ___ and activation leads to

Answer 12

adipose tissue

-activation = lipolysis

Question 13

reactivity of B1 to norep and ep

Answer 13

Epi = NE

Question 14

reactivity of B2 to norep and ep

Answer 14

Epi»NE

Question 15

reactivity of norep and ep to B3

Answer 15

NE >Epi