09/18 - Susceptibility to Periodontal Diseases Flashcards

1
Q

What is the definition of susceptibility?

A

the state of being easily affected, influenced, or harmed by something

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2
Q

True or false: Different forms of periodontitis may have different etiologic factors.

A

true

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3
Q

The magnitude and quality of the periodontal tissue changes are determined not only by the bacteria, but also by ___ and ___.

A
  • the patient’s genetics

- environmental modifiers

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4
Q

What 3 factors determine the clinical disease severity of periodontitis?

A
  • genetic modifiers
  • specific bacteria
  • environmental modifiers
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5
Q

True or false: Periodontopathic bacterial flora is necessary but not sufficient for disease.

A

true

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6
Q

What is the odds ratio that smoking will increase periodontitis? For diabetes?

A
  • smoking: 2.5-3.7

- diabetes 2.8-3.4

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7
Q

What is the definition of Mendalian inheritance? What are the modes of inheritance? What is it also known as?

A
  • the manner by which genes and traits are passed from parents to their children
  • autosomal dominant, autosomal recessive, x-linked dominant, and x-linked recessive
  • AKA classical or simple genetics or single gene disorders
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8
Q

What is the definition of chromosome disorder?

A

an abnormal condition due to something unusual in an individual’s chromosomes

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9
Q

What is the definition of complex gene disorders? What are some examples?

A
  • conditions caused by the effects of multiple genes in combination with lifestyle and environmental factors
  • ex. cardiovascular disease, diabetes mellitus, and destructive periodontal disease
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10
Q

What is the definition of polymorphism?

A

exists when two or more different phenotypes exist within different individuals within the same population; in the context of genetics, it refers to a region of the genome that varies between individual members of the population in such proportions that the rarest of them cannot be maintained just by recurrent mutation

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11
Q

What is the definition of SNP? How often are they seen?

A
  • single nucleotide polymorphisms are the most common type of genetic variation; each represents a difference in a single nucleotide
  • occur normally throughout a person’s DNA, once in every 300 nucleotides so there are roughly 10 million SNPs in the human genome
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12
Q

What 3 things do complex genetic disorders involve?

A
  • multifactorial (polygenic) interactions
  • gene-gene interactions
  • gene-environment interactions
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13
Q

What are the 5 characteristics of complex gene traits?

A
  • common in population
  • no clear familial transmission
  • adult age onset
  • environmental factors etiologic too
  • combination of multiple small genetic and environmental factors
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14
Q

Which type (simple or complex) genetic disease is described?

  • single etiologic gene
  • gene has major effect
  • simple pattern of transmission
A

simple genetic disease

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15
Q
Which type (simple or complex) genetic disease is described?
- phenotype usually less modified by environmental interactions
A

simple genetic disease

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16
Q
Which type (simple or complex) genetic disease is described?
- chronic onset
A

complex genetic disease

17
Q

Which type (simple or complex) genetic disease is described?

  • many genes may contribute to etiology
  • contribution of each gene is individually small and cannot cause disease alone
  • complex pattern of transmission
A

complex genetic disease

18
Q
Which type (simple or complex) genetic disease is described?
- usually acute onset
A

simple genetic disease

19
Q
Which type (simple or complex) genetic disease is described?
- phenotype continuum; environmental factors can be very important to phenotype
A

complex genetic disease

20
Q

What 3 types of defects may make a person more susceptible to periodontitis?

A
  • structural defects (mucosa, collagen)
  • immune response defects (cytokines)
  • white blood cell defects (neutrophils, macrophages)
21
Q

What are the 4 reasons why it is not realistic to expect a single gene polymorphism (SNP) will be diagnostic for a complex genetic disease?

A
  • no single gene contributes enough to cause disease alone (in contrast to Mendelian disease)
  • environmental factors are important and required to cause disease
  • need to study many (thousands) of people in standardized way to identify an association between a SNP and disease state
  • human populations are mixed in terms of gene polymorphisms and environmental exposures, making studies difficult to control