065 Neuropathology

Question 1

What initial mutation must occur in all gliomas?

Answer 1

Mutation in isocitrate dehydrogenase

Question 2

What mutation in patients with in born error can result in glioma?

Answer 2

2-hydroxy-glutarate

Question 3

After IDH mutation, what mutation will lead to astrocytoma?

Answer 3

Mutation in p53

Question 4

After IDH mutation, what will mutation in 1p/19q result in?

Answer 4

Oligodendroglioma

Question 5

In which age group do astrocytomas normally arise?

Answer 5

Old

Question 6

In which age group do oligodendrogliomas usually rise?

Answer 6

Young