04 hemostasis

Question 1

1 cause of thrombocytopenia in kids and adults

Answer 1

ITP

Question 2

ITP - mechanism / pathology

Answer 2

IgG against platelets (esp. GpIIb/IIIa) are produced by plasma cells in SPLEEN and platelets get eaten up in the SPLEEN

Question 3

bernard-soulier

Answer 3

GpIb deficiency - bad adhesion - BIG platelets on smear

abnormal ristocetin test

Question 4

Glanzmann

Answer 4

GpIIb/IIIa - Aggregation - abnormal ADP test

Question 5

dense granules

Answer 5

Calcium and ADP

Question 6

alpha granules

Answer 6

vWF, fibrinogen, PDGF, PF4

Question 7

activator of 1. intrinsic 2. extrinsic pathways

Answer 7

1. collagen - factor XII

2. tissue thromboplastin - VII

Question 8

which factors are represented by both PT and PTT

Answer 8

II, V, X, fibrinogen

Question 9

mixing study differentiates between ? and ?

Answer 9

hemophilia A and Factor VIII inhibitor (will not correct PTT if inhibitor)

Question 10

protein C and S turn off factors ? and ?

Answer 10

V and VIII

Question 11

why do OCPs increase clot risk

Answer 11

estrogen increases coag factor production by liver