04 Clonality Flashcards
0
Q
Alpha and light chain
A
Vj->VJC
1
Q
Beta and heavy chain recombinaton
A
DJ-> VDJ–> VDJC
2
Q
RAG1 and RAG2
A
VDJ recombinases- Deficiencies can cause SCID
3
Q
IL7
A
ProB cell to PreB cell differrentiatting cytokine
4
Q
B cell tolerance
A
1) Clonal deletion in BM from binding membrane bound self atnigen too tightly
2) Binding soluble antigen from beginning of cell life at low levvels leads to tolerance like drug tolerance.
3) Peripheral anergy as complementary T cells would be negatively selected for and will not provide necessary costimulation for b cell maturation
