03 - Immunopathology

Question 1

Pattern receptors of innate immune system (PRR)

Answer 1

toll-like receptor (TLR)
NOD-like receptor 
Rigi-like receptor (RLR)
C-type lectins (CLR)
scavenger receptor

Question 2

antimicrobial peptides of innate immune system

Answer 2

defensins
cathelin
protegrin
Histatin
secretory leukoprotease inhibitor
probiotics 
granulsyin

Question 3

cells involved with innate immune system

Answer 3

macrophages
dendritic cells
NK cells
NK T-cells
Neutrophils
Eosinophils
Basophils
epithelial cells

Question 4

Cytokines involved in adaptive immune response

Answer 4

autocrine
paracrine
endocrine –> mediate host defence + inflammation (recruit, direct + regulate adaptive immune response)

Question 5

pattern recognition receptors

Answer 5

inclusive term for antigen recognition receptor in INNATE system

Question 6

C type lectin family roles

Answer 6

collectins –> manose-binding lectin + surfactant protein A&D

Bind via carbohydrate-recognition domains (CRDs)

role in neutralisation pathogens
role in recruitment pathogens
role in recruitment of adaptive response

Question 7

Role of macrophages

Answer 7

Phagocytose + kill bacteria

Produce antimicrobial peptides –> bind LPS

Produce inflammatory cytokines

Question 8

Role of Plasmacytoid dendritic cells (DCs)

Answer 8

produce INTERFERON (IFN-) –> anti-tumour + antiviral activity (found T cell zones of lymphoid organs)

circulate in blood

Question 9

Myeloid dendritic cells

Answer 9

strong producers of IL-12 and IL-10

Question 10

Role of Natural killer cells (NK)

Answer 10

lymphocyte both T cell and NK surface markers

they recognise lipid antigens –> CD1 molecules

Kill host cells with intracellular bacteria

Question 11

role neutrophils

Answer 11

phagocytose and kill bacteria

produce antimicrobial peptides

Question 12

role eosinophils

Answer 12

kill invading parasites

Question 13

role mast cells and basophils

Answer 13

AQ