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Ncs > 0222 > Flashcards

0222 Flashcards

1
Q

Gene expression is regulated by cellular proteins known as

A

Tramscription factors

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2
Q

Control of transcription factor is dependent on

A

Concentration

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3
Q

Can deletion of a gene tell whether it is permissive or instructive

A

No

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4
Q

What is cell fate?

A

The fate of a cell is defined as what the cell give rise to

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5
Q

What is differentiation

A

The development of specialized cell types; commitment lf the cell

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6
Q

What is specification and determination

A

The early (reverisble) and late (irreversible) stage kf the cell-fate commitment

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7
Q

Instructive cues

A

Provide information that actively leads to program of development or differentiation

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8
Q

What controls dorsoventral patterning in the spinal cord

A

Sonic hedgehog

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9
Q

Perimissive cues

A

Required for differentiation but does not itself provide information about cell fate specification

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10
Q

What is it called when neuro-ectoderm becomes subdivided into specific regions

A

Determination

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11
Q

What expression shows how neuro-ectoderm becomes subdivided

A

Homeodomain transcription factors

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12
Q

What family controls limb development in drosophila

A

Hedgedehog family

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13
Q

What is the most prominent ventralizing factor

A

Shh

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14
Q

What secretes shh

A

First by the notochord, then by the floor plate of the spinal cord

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15
Q

Is there a concetration gradient gradient of shh from ventral to dorsal

A

Yes

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16
Q

What haooens when shh is missing or blocked with an antibody

A

There is no floor plate plate or any ventral neurons including motor neurons

17
Q

What is the Shh receptor on the membrane

A

PTC which interacts with SMO

18
Q

What inhbits SMO g protein receptor

A

Unoccupied PTC

19
Q

What release SMO inhibiton

A

Binding of Shh to PTC

20
Q

What transcription factor is activated by activated SMO

A

Gli

21
Q

Signaling factors for gli proteins

A

Wnts

22
Q

What do gli proteins do after activated by SMO

A

Activate or repress the transcription of genes for ptc and homeodomain transcription factors

23
Q

What does gli do when it goes to domain

A

It represses to turn off gli and ptc

24
Q

What are class 2 transcription factors

A

Nkx2.2 and Nkx6.1

25
Q

Class 1 transcription factors

A

Pax6 and Dbx2

26
Q

 What promotes expression of MNR2

A

Nkx6.1

27
Q

What are the prices the expression of MNR2

A

Nkx2.2 & irx2

28
Q

What sounds in the number to secrete BMP

A

Roof plate

29
Q

What are the first three divisions in early brain development

A

Prosencephalon and mesencephalon and rhombencephalon

30
Q

What are the most structurally obvious divisions in early ain development 

A

Rhombomeres 

Ncs (3 decks)

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