012915 endocrine physio

Question 1

hormone classes

Answer 1

steroids
thyroid hormones
polypeptides, proteins, glycoproteins, catecholamines

Question 2

which hormone class is lipophilic?

Answer 2

steroid

thyroid

Question 3

steroids are all synthesized from

Answer 3

some form of cholesterol

Question 4

glycoproteins (LH, FSH, TSH, hcG) all have the same of what kind of unit?

Answer 4

alpha (specificity is in beta unit)

Question 5

rate limiting step for all steroidogenic pathways

Answer 5

steroidogenic acute regulatory protein (STAR) mediation of cholesterol uptake from the cytosol to the inner mito membrane where P450scc is

Question 6

thyroid hormone receptors are located where

Answer 6

in nucleus

Question 7

how can T4 be made more potent?

Answer 7

by being converted to T3 in target tissue by the enzyme iodinase (like the ex of testosterone being converted to DHT)

Question 8

describe positive feedback loop in oxytocin (delivery)

Answer 8

stretch of cervix-signal goes to hypothalamus, which goes to posterior pituitary to stimulate oxytocin release to increase uterine contraction

Question 9

in secondary hypofxn, what is the target gland fxn level and the controlling hormone level?

Answer 9

target gland fxn-decreased

controlling hormone-decreased or normal

Question 10

ex of secondary hypofxn

Answer 10

80% of corticotrophs (ACTH-producing cells in anterior pituitary) are gone. the 20% remaining can’t make enough ACTH to keep cortisol normal

Question 11

in secondary hyperfxn, what are target gland fxn level and controlling hormone levels?

Answer 11

target gland fxn-increased

controlling hormone-increased or normal