011615 microbiota Flashcards

1
Q

mucins’ role in host defense

A

binds some commensals
bacterial exclusion
containment of secreted antibodies and antimicrobials

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

paneth cell AMPs-give ex

A

defensins
lysozyme
phospholipase A2
RegIIIgamma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

predominant immunoglobulin secreted as a defense in the mucosal areas

A

IgA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

how is mucosal IgA inducted?

A

1st way: bacteria is engulfed by dendritic cell. DC goes to mesenteric lymph node to induce B cell activation. get plasma cell secretion of IgAs

2nd way: M cell encounters bacteria. then activatres B cells in Peyer’s patches

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

activities of IgA

A

surrounds microbe and repels attachment to mucosal surface

mucus trapping-may associate with mucins and trap microbes in mucus blanket

virus neutralization

etc

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

if you lack a good immune system, what happens?

A

commensal microbiota can invade

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

healthy microbiota contains what

A

balancec omposition of three major classes of bacteria:

symbionts, commensals, pathobionts (live as commensals but have potential to induce pathology)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

microbial composition is determined by

A

site in GI
O2 tension
innate immune factors
host nutrition/diet

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

role of intestinal microbiome

A

protective against pathogens
induce immune system development
metabolic fxns

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

fxn of short chain fatty acids

A

commensal bacteria ferment nondigestable dietary polysaccharides to produce short chain fatty acids

SCFAs regulate PMNs, DCs, macrophages, epithelial cells. SCFAs regulate expression of virulence factors on bacterial pathogens so that they are not so toxic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

abnormalities in composition of microbiome can result in increased risk of autoimmune, allergic, infectious and metabolic diseases: true or false

A

true

How well did you know this?
1
Not at all
2
3
4
5
Perfectly