01-TheBigPicture Flashcards
Medicine
- Systems
- Aetiologies
- Medical Problem Solving
Systems
Cardiology Pulmonary Gastroenterology Nephrology Endocrinology Rheumatology Hematology Neurology
Aetiologies
- Infection
- Neoplastic
- Autoimmune
- Atherosclerosis
- Toxin
- Psychogenic
Cardiology
Hypertension Lipid disorders Coronary artery disease Arrhythmias Heart Failure Valvular heart disease Pericardial disease EKG
Pulmonary
Obstructive lung disease ILD VTE ICU Pleural disease CXR PFT
GI
- Peptic ulcers GI bleeding
- Esophageal diseases
- Pancreatico-biliary
- Intestinal disease
- Liver disease
Nephrology
Acid-base disorders Electrolyte disorders AKI Glomerular diseases CKD
Endocrinology
DM Thyroid Calcium and bone disorders Reproductive endocrinology Neuroendocrine Adrenal
Rheumatology
Arthritis Vasculitis Office orthopedics
Hematology
Anemia Platelet disorders Coagulation MDS
Oncology
- Colorectal
- Breast
- Ovarian
- Leukemia
- Lymphoma
- Genitourinary
- Plasma cell dyscrasias
Neurology
Migraine Stroke Seizures Movement disorders
Headache
Primary: Migraine, Tension, TAC Secondary: SAH, Meningitis, Tumor, Arteritis, Trauma, Central venous thrombosis etc
Stroke
Ischemic Hemorrhagic
Ischemic stroke mechanisms
Large artery atherosclerosis: Carotid/Vertebrobasilar Lacune (small-vessel disease) Cardiac embolism Arterial dissection Vasculitis Nonatherosclerotic vasculopathy: Eg: FMD Hematologic disorders/coagulopathy Watershed infarction Drug abuse Migraine Venous infarction
Seizures
Partial Generalized Basis: single versus both hemispheres
Partial Seizures
Simple Complex Basis: Level of consciousness during seizure
Movement Disorders
- Hyperkinetic
- Hypokinetic
- Other
- Hyperkinetic disorders
- Tremor
- Chorea, athetosis, and ballism
- Dystonia
- Myoclonus
- Urge to move: Tics, restless legs syndrome, akathisia
- Hypokinesis
- Parkinsonism
- Parkinson disease
- Catatonia (often classified as a psychiatric disorder)
- Apraxia (often classified as a cognitive disorder)
- Other topics in movement disorders:
- Ataxia
- Drug-induced movement disorders
- Psychogenic movement disorders
Hyperkinetic disorders
- Tremor
- Chorea, athetosis, and ballism
- Dystonia
- Myoclonus
- Urge to move: Tics, restless legs syndrome, akathisia
Hypokinetic movement disorders
- Parkinsonism
- Parkinson disease
- Catatonia (often classified as a psychiatric disorder)
- Apraxia (often classified as a cognitive disorder)
Movement disorders other than hypokinetic and hyperkinetic
- Ataxia
- Drug induced
- Psychogenic
Ophthalmology
- Cataracts
- Age related macular degeneration
- Primary open angle glaucoma
- Side effects of common ocular medicines
- Diabetic retinopathy
- Causes of sudden visual loss
- Causes of red eye
- Eye infections
- Ocular complications of HIV
- Bacterial and viral conjunctivitis
- Diseases of the eyelid
- Blepharitis
- Hordeolum
- Chalazion
- BCC
- Ocular effects of systemic therapy
- Eye in rheumatologic disease
Chest Radiology
- Nodules and masses
- Infiltrates
- Pleural effusions
Infiltrates
- Alveolar
- Interstitial
Colorectal cancer: pathological classification
- Carcinoma
- 90% adenocarcinoma
- Misc
- Miscellaneous
The vast majority of tumors of the colon and rectum are carcinomas. Other histologic types (neuroendocrine neoplasms, hamartomas, mesenchymal tumors, lymphomas) are relatively unusual.
Carcinomas: >90% are adenocarcinomas.
Colorectal cancer: classification by location
- Rectal cancers: Distal to peritoneal reflection or less than 12 to 15 cm from anal verge
- Colon cancer: Proximal
OpenQuestion: which is it peritoneal reflection or length?
Inheritable colon cancer syndromes
- Polyposis syndromes
- FAP
- Gardener
- Turcot
- Peutz-Jegher
- Juvenile Polyposis
- Nonpolyposis: Lynch Syndrome/HNPCC
Breast Cancer: (site, invasion, grade)
- DCIS
- LCIS
- Invasive breast cancer
Ovarian cancers
- Surface Epithelial
- Many others:
- germ cell (15%), sex cord-stromal (10%), metastases (5%), miscellaneous
Surface epithelial tumors are classified by cell type (serous, mucinous, endometrioid, etc) and atypia (benign, borderline [atypical proliferation, low malignant potential] or malignant; malignant may be invasive or non-invasive)
Genitourinary cancers
- Prostate
- Urothelial
- Bladder
- Ureteral
- Renal pelvis
- RCC
- Testicular
Lymphomas vs Leukemias
- Leukemias: blood and bone marrow,
- lymphomas: lymphoid tissues.
- Some diseases, like CLL, can have features of both.
Lymphomas
- Hodgkin
- NHL
- DLBCL
- Follicular
- Others
Diffuse large B-cell lymphoma (DLBCL): most common NHL
Non-Hodgkin Lymphomas
-
Indolent
- Follicular lymphoma, grade 1 or 2
- Marginal zone lymphoma, including mucosa-associated lymphoid tissue lymphoma
- CLL/SLL
- Most skin lymphomas
-
Aggressive
- Follicular lymphoma, grade 3B
- Diffuse large B-cell lymphoma
- Mediastinal large B-cell lymphoma
- Peripheral T-cell lymphoma
- Mantle cell lymphoma
- Burkitt lymphoma*
- Acute lymphoblastic lymphoma/leukemia (ALL) *
Lymphoma Leukemia Overlaps
- CLL
- Hairy cell leukemia (Rare B-cell leukemia)
Plasma cell dyscrasias
- MGUS
- Multiple myeloma
- Plasmacytoma
- POEMS
- AL Amyloidosis
- Waldenström macroglobulinemia
- Cryoglobulinemia
Oncology: selected topics
- Cancer of unknown primary
- Oncologic emergencies
- Paraneoplastic syndromes
- Cancer chemotherapy
Oncologic emergencies
- SVC syndrome
- Spinal cord compression
- Pericardial tamponade
- Venous thrombosis
- Metabolic
- Hypercalcemia
- Hyponatremia
Paraneoplastic
- Neurologic
- Rheumatologic
- Endocrinologic
- Non-bacterial thrombotic endocarditis
- Cutaneous syndromes
Paraneoplastic.Neurologic
- Encephalomyelitis
- Cerebellar degeneration
- Limbic encephalitis
- Stiff person syndrome
- Lambert-Eaton
Neoplastic.Rheumatologic
- Hypertrophic osteoarthropathy
- Dermatomyositis/polymyositis
Neoplastic.endocrinologic
- Carcinoid
- Cushing
- Acromegaly
- Hypercalcemia
- SIADH
Oncology.Chemotherapy
- Toxicities
- Tumor lysis syndrome
- Febrile neutropenia
- Typhlitis
Oncology.Chemotherapy.Toxicities
- Acute
- Delayed
Nephrology.Acid-Base
- Metabolic acidosis
- With increased gap
- With normal gap
- With low gap
- Metabolic alkalosis
- Respiratory acidosis
- Respiratory alkalosis
- Renal tubular acidosis
- Type 1
- Type 2
- Type 4
GI.Esophageal-diseases
- GERD
- Esophagitis
- Barrett’s
- Structural-disorders
- Esophageal-cancer
- Dysphagia-odynophagia: #ClinicalTechnique
- Esophageal-dysmotility
- Esophageal-cancer # Why not under cancer
9.
GI.esophagus.structural-disorders
- Zenker
- Webs-and-rings
- Schatzki
- Plummer-Vinson
- Hiatal-hernia
- Sliding
- Para-esophageal
Autoimmune.Scleroderma
-
Localized
- Linear (in kids, dermatomal)
- Morpheaeform
-
Systemic
- Diffuse cutaneous SSc (dcSSc)
- Limited cutaneous SSc (lcSSc)
- SSc sine scleroderma: only internal organ involvement
- Environmentally-induced scleroderma
- Overlap syndromes
Critical-Care
- Acute respiratory failure
- Physiology
- Mechanical ventilation
- Invasive
- Non-invasive
- ARDS
- Sepsis
- Shock
- Toxin-exposure
- Analgesics-sedatives
- Cardioactive
- Toxins That Alter Hemoglobin/Oxygen-Binding Properties
- Alcohols