01 - serum chem Flashcards
(BUN)
- 3 causes of increase?
- ↓ GFR
- ^protein diet/GI hemorrhage
- ^protein catabolism
(BUN)
- 4 causes of ↓ BUN
- liver failure/shunts
- low protein diets
- PU/PD (cause and effect)
- young animals
(creatinine)
- two causes of increase?
- ↓ GFR
- high protein diet
(creatinine)
decrease not significant
(Calcium)
- 6 causes of decrease
- ↓albumin
- renal failure
3-4. GI (pancreatitis, malabsorption)
5-6. (endocrine) 1° hypoparathyroidism, malabsorption (PLE)
(Calcium)
- 6 causes of ^?
- ^albumin
- vitamin D
- cancer (lymphoma, anal sac, thymoma)
- renal failure
- Addison’s
- 1° hyperparathyroidism
3 causes of ↓Ca, normal P
- ↓ albumin
- acute pancreatitis
- drugs (glucocorticoids)
2 causes of ↓Ca, ^P
- 1° hypoparathyroidism
- ethylene glycol
1 cause of ↓Ca, ↓P
- decreased intestinal absorption
two causes of ^Ca, ↓ to normal P
- 1° hyperparathyroidism
- hypercalcemia of malignancy (lymphoma, multiple myeloma, anal sac)
two causes of ^Ca, ^ P
- ^ vitamin D
- addison’s (^intestinal/renal absorption)
1 cause of normal Ca, ^P
- DECREASED GFR most common
1 cause of normal Ca, ↓P
- shift into cells with hyperglycemia and ^insulin
(rarely significant)
1 cause of ^Mg
decreased GFR
(↓albumin/↓globulin)
- 5 causes
- overhydration
(non-selective loss)
- third space
- GI disease (esp PLE)
- burns
- external hemorrhage
↓albumin/normal globulins
2 causes
- non-selective loss + inflammation balancing globulin loss
(third space, GI, cutaneous, external hemorrhage + inflam)
- selective loss from kidney
(↓albumin/^globulins)
- 5 causes
- inflammation
- hematopoeitic malignancy (lymphoma, multiple myeloma)
- liver failure
- PLE
- starvation
(^globulins/normal albumin)
2 causes?
- inflammation
- paraneoplastic
(^globulin/^albumin)
1 cause
dehydration (or dehydration + inflammation)
5 dilutional causes of ↓Na
- preg/neonate
- CHF
- postrenal azotemia/uroabdomen
- cirrhotic liver dz
- DM
(↓Na)
- 4 causes when loss of Na > water
- diarrhea
- renal dz (diuresis)
- ketonuria
- addisons
↓ Na
4 causes when loss of Na = water, replaced by water
- hemorrhage
- 3rd space loss
- burns
- diarrhea
two causes of ^Na
- decreased water intake
- loss of water > Na: panting, some renal/GI
(↓ chloride)
- if proportional to Na, see sodium
- if disproportionate, what two causes?
- with ^bicarb: upper GI fluid loss/stasis
- with normal/dec bicarb: probably mixed acid/base disorder
(^chloride)
- if disproportionate to Na
what two causes?
- w/ dec bicarb: metabolic acidosis
- with normal/^bicarb: probably mixed acid/base disorder
(↓ potassium)
- two causes?
- anorexia
- intracellular shift (^insulin/glucose, alkalosis)
(^ potassium)
- 4 causes
- failure of elimination (oliguria/anuria/post-renal)
- addison’s
- insulin/deficiency resistance (DM)
- metabolic acidosis (translocation)
(bicarbonate)
- 1 cause of increase?
- loss of acid (GI or renal)
↓ bicarb
- with high anion gap
- with normal anion gap
- excessive acid: ketoacidosis, lactic acidosis, uremic acidosis
- ^ bicarb losses (GI or renal)
(decreased anion gap)
2 causes
- low albumin
- ^ cationic proteins (rare, gammopathy)
(^anion gap)
- usually due to what?
- accumulation of anionic acids (lactic, keto, uremic)
(^bilirubin)
3 broad causes
pre-hepatic cholestasis
hepatic cholestasis
post-hepatic cholestasis
(^bilirubin)
evidence of pre-hepatic cholestasis
- anemia (usually regen)
RBC morph (sphero, heinz, schistocytes)
(^bilirubin)
- 4 causes of hepatic cholestasis
dec liver fx (↓BUN, glucose, albumin, cholesterol, low USG, ^Pt)
sepsis (inflam leukogram, hypoglycemia, Cx)
lepto (+ renal azotemia)
anorexia (+/- cats, not dogs)
^bilirubin
causes of post hepatic cholestasis
(blockage of bile caniculi or ducts)
choleliths, mucocele, neoplasia, inflammation, pancreatitis
5 causes of ^ALP
- post-hepatic cholestasis
- bone-growth/disease
- corticosteroids (cushing’s)
- phenobarb
- metabolic: DM, hyperT4
(^GGT)
2 causes
post-hepatic cholestasis or biliary hyperplasia
inductino by drugs or hormones (similar to ALP: steroids, phenobarb)
(^ALT)
6 causes
- 1° liver dz (inflam, infectious, neoplastic, toxic, trauma, fatty infiltration)
(secondary)
- ↓perfusion/hypoxia
- post-hepatic cholestasis
- intestinal dz
- pancreatic dz
- endocrine (DM, hyperT4)
(^AST)
- +^ALT = ?
- ^CK = ?
- hepatocellular dmg
- skeletal muscle dmg
(^amylase)
3 causes
- ↓GFR
- intestinal dz
- pancreatitis/pancreatic neoplasia
(↓ glucose)
2 broad causes
↓production
excessive use/cellular uptake
↓glucose from ↓ production
4 causes
- liver failure
- sepsis
- hypoadrenocorticism
- young animals/small breed
↓glucose from escessive use/cellular uptake
3 causes
- sepsis
- insulin overdose
- paraneoplastic (insulinoma)
(^glucose)
- 6 causes
- post-prandial
- stress
- DM
- Cushing’s
- hyperT4 (Cats)
- pancreatitis
3 causes of ↓cholesterol
- liver failure
- addison’s
- PLE
^cholesterol
7 causes
- post-pradial
- DM
- Cushing’s
- pancreatitis
- hypoT4
- post-hepatic cholestasis
- nephrotic syndrome