πͺπ»&π€ Flashcards
A band
DARK
stacked set of thick filaments (myosin) + portion of thin filaments (actin)
actin overlaps on both ends of the thick filaments
H zone
lighter area in the middle of the A band, where the thin filaments do not reach
M line
extends vertically down the middle of the A band; is in the middle of the H zone
I band
LIGHT
remaining portions of the thin filaments
Z line
dense, vertical line, located in the middle of each I band;
flat cytoskeletal disc that connects the thin filaments of two adjoining sarcomeres
sarcomere
smallest unit of skeletal muscle that can undergo muscle contraction;
area between two Z lines
Transverse (T) tubules
location?
runs from _______ to the _______ of the muscle fibre => ____ (slow/rapid) spread of the AP
at the junction of A and I band, where surface membrane dips into the muscle fibre;
runs from surface to the central portions of the muscle fibre => rapid spread of the AP
sarcoplasmic reticulum (SR) is modified _______ that consists of fine network of ____________ enclosed compartments surrounding each myofibril like a __________ [think clothing]
sarcoplasmic reticulum (SR) is modified ENDOPLASMIC RETICULUM that consists of fine network of INTERCONNECTED MEMBRANE enclosed compartments surrounding each myofibril like a MESH SLEEVE
lateral sacs (terminal cisternae) separated from adjacent T tubules by \_\_\_\_\_\_, \_\_\_\_ [substance] storages; the spread of \_\_\_\_ down a T tubule triggers release of \_\_\_\_ [substance] from the SR into \_\_\_\_\_\_\_ [substance/organelle in the cell]
separated from adjacent T tubules by a slight gap, Ca2+ storages;
the spread of AP down a T tubule triggers release of Ca2+ from the SR into cytosol
foot proteins aka ryanodine receptors
bridge the gap between lateral sacs and T tubules, are Ca2+ release channels
dihydropyridine receptors are also called \_\_\_\_\_\_\_\_\_ why are they called dihydropyridine? nature of their work? what electrical activity activates these channels?
= T tubule receptors;
can be blocked by the drug dihydropyridine
voltage-gated sensors;
local depolarisation activates these channels
AP β> local depolarisation β> T tubule receptors trigger the opening of _______ β> opening of the ________ not directly associated with the ________ β> Ca2+ released into _______ β> exposure of the ______ on the ____ molecules so that they can link with ________ cross bridges β> beginning of the cross bridge cycle
ryanodine receptors ryanodine receptors T tubule receptors cytosol binding sites actin myosin
Cardiac muscle AP
________ plateau = _________ contraction => ________ (adequate/inadequate) ejection time
plateau due to activation of ________ channels (why this name?)
PROLONGED plateau = PROLONGED contraction => ADEQUATTE ejection time
plateau due to activation of L-TYPE Ca2+ channels (L because opened for Long)
actin is build from chains thatβ¦.
intertwine
tropomyosin looks like a _____ [sewing kit], physically covers ______
thread like
actin
troponin is made up of 3 subunits, what does each bind to?
one binds to tropomyosin
one to actin
one combines with Ca2+ ions released from lateral sacs
Myosin looks like ______ [sports gear], _____ is twisted
globular head has two sites, what does each bind to?
like a golf club
shaft is twisted
globular head has two sites: one for binding of actin, the other one for myosin ATPase
A band (during contraction)
stays same width (A band = thick filaments, hence stays the same)
I band (during contraction) width \_\_\_\_ (decr./same/incr.) \_\_\_\_\_\_ filaments are \_\_\_\_ overlapping \_\_\_\_\_ filaments
width π½
THIN filaments are NO LONGER overlapping THICK
H zone (during contraction)
width π½ (thick filaments not overlapping thin)
cross bridge cycle has 4 steps:
binding
power stroke
detachment
binding
(1st) Binding [of the cross bridge cycle]
what binds to what?
myosin cross bridge binds to actin molecule
Power stroke [of the cross bridge cycle]
what happens?
what is the consequence?
cross bridge bends, pulling thin myofilament inward
Detachment [of the cross bridge cycle]
it happens at the end of what?
what happens later?
cross bridge detaches at end of power stroke and returns to normal conformation
(2nd) Binding [of the cross bridge cycle]
what binds to what? what is the next step?
cross bridge binds to more distal actin molecule;
cycle repeats
CNS (____) β> ______ β-> _____ & ______ & _______ & _______
central nervous system PNS = peripheral nervous system somatic efferent enteric (ENS) autonomic (ANS) somatic and visceral afferent
ANS β-> ______ & ______
sympathetic division
parasympathetic division
SNS transmitters (2), specify order
pregangionic neurone: ACh (cholinergic)
postganglionic neurone: usually NA = noradrenaline (adrenergic)
PSNS transmitters (2), specify order
pregangionic neurone: ACh (cholinergic)
postganglionic neurone: ACh (cholinergic)
ACh is synthesised byβ¦
choline acetyltransferase (CAT)π±π±π±
ACh is degraded to _____ and _____ by
acetate
choline
acetylcholinesterase (AChE)
type of G protein: \_\_\_\_ G protein coupled receptor: M1 action: \_\_\_\_\_\_ affected organ(s): stomach effect on the organ: \_\_\_\_\_\_
Gq
simulation of phospholipase C
πΌ acid secretion
type of G protein: Gi G protein coupled receptor: \_\_\_\_ action: inhibition of adenylyl cyclase & \_\_\_\_\_\_\_\_\_ affected organ(s): heart effect on the organ: \_\_\_\_\_\_
M2
opening of K+ channels
π½ rate
type of G protein: Gq
G protein coupled receptor: _____
action: simulation of phospholipase C
affected organ(s): salivary glands [effect?], ______ [contraction]
- _______ is indirectly relaxed by ____ receptor activation due to release of ______ from neighbouring endothelial cells
M3
increased secretion
visceral smooth muscle
Vascular smooth muscle
M3
nitric oxide
type of G protein: Gs G protein coupled receptor: \_\_\_\_ action: \_\_\_\_\_\_\_\_ affected organ(s): heart effect on the organ: \_\_\_\_\_\_
Ξ²1
stimulation of adenylyl cyclase
πΌ rate & force
type of G protein: \_\_\_\_ G protein coupled receptor: Ξ²2 action: stimulation of adenylyl cyclase affected organ(s): \_\_\_\_\_\_ effect on the organ: \_\_\_\_\_\_
Gs
bronchial and vascular smooth muscle
relaxation
type of G protein: Gq G protein coupled receptor: \_\_\_\_ action: stimulation of phospholipase C affected organ(s): \_\_\_\_\_ effect on the organ: \_\_\_\_\_\_
Ξ±1
vascular smooth muscle
contraction
type of G protein: \_\_\_\_\_ G protein coupled receptor: Ξ±2 action: \_\_\_\_\_\_\_\_ affected: NorAd release effect: \_\_\_\_\_\_
Gi
inhibition of adenylyl cyclase
inhibition
NorAd is reuptaken by two transporters:
uptake 1 (U1), and uptake 2 (U2)
NorAd is metabolised by two enzymes:
monoamine oxidase (MAO,) and catechol-O-methyltransferase (COMT)
examples of synergistic muscles (synergists) in upper limb (2 pairs)
biceps brachii & brachialis
triceps brachii & anconeus
examples of flexors in upper limb (2)
Biceps brachii
brachialis
examples of extensors in upper limb (2)
triceps brachii
anconeus
axial muscles controlβ¦
movements of the trunk (maintaining posture)
proximal (or girdle) muscles are found in _____, ______, ______ and ______
they [action]
the shoulder, elbow, pelvis and knee
mediate locomotion
distal muscles move ______, _____, and ______
they [action]
the hands
feet
digits
allow fine manipulation of objects by the hand
Axons of LMNs (lower motor neurones) exit the spinal cord in _________
the ventral roots
Each ventral root joins with a ________ to form a ___________ (30 pairs) which
contains sensory and motor fibres
dorsal root
mixed spinal nerve
Motor neurones
belong to a spinal segment: _______ (C) ______, _______ (T) _______, ______ (L) ______ and ______ (S) _____
cervical 1-8
thoracic 1-12
lumbar 1-5
sacral 1-5
Motor neurones are not distributed equally within the spinal cord: greater number in the ________ (______) supplying the arm and _________ (______) supplying leg
cervical enlargement (C3 - T1) lumbar enlargement (L1-S3)
Motor neurones that innervate distal and proximal musculature are mainly in __________ of the spinal cord, whereas those innervating the axial musculature _________
lumbar-sacral segments
occur at all levels