❤️ Flashcards
adventitial layer
connective tissue
medial layer
smooth muscle tissue
intimal layer
endothelial cells
elastic artery (% composition)
arteries: ELective Can Surely Educate
elastic tissue > connective tissue > smooth muscle > endothelium
arteriole (% composition)
arterioles like to perform SCEEnes
smooth muscle > connective tissue > elastic tissue & endothelium [both 10%]
capillary (% composition)
95% endothelium
5% basal lamina (connective tissue)
venule (% composition)
Venules Can be like ENdangered blue Snakes🐍🐍🐍
connective tissue > endothelium & smooth muscle [both 20%]
NO elastic tissue [0%]
vascular tone (def.)
a state of partial constriction (displayed by arteriolar smooth muscle)
vascular tone is affected by:
myogenic activity
sympathetic activity
vascular tone is important because… [tonic]
tonic activity makes it possible to decrease / increase contractile activity (vasodilation/vasoconstriction)
flow rate depends on…
the pressure difference (ΔP)
resistance to blood flow depends upon 3 factors:
blood viscosity Ƞ
vessel length L
VESSEL RADIUS r
2-fold change in vessel radius will produce…
a 16-fold change in flow
a slight change in radius…
brings about a notable change in flow
🔼activity in the sympathetic nerves to the ❤️…
🔼 HR (tachycardia)
🔼activity in the parasympathetic nerves to the ❤️…
🔽HR (bradycardia)
🔼HR
tachycardia
🔽HR
bradycardia
PSNS (vagus nerve) releases…
acetylcholine (ACh; muscarinic receptors)
SNS releases…
noradrenaline (NorAd, US: norepinephrine; β1-adrenergic receptors)
ACh and NorAd alter the activity of the ________ in the innervated cardiac cells
cAMP 2nd messenger pathway
ACh is coupled to ___(1)___ G-protein that ___(2)___ activity of the cAMP pathway
(1) an inhibitory
(2) reduces
NorAd is coupled to ___(1)___ G-protein that ___(2)___ the cAMP pathway
(1) a stimulatory
(2) accelerates
PSNS 🔽 HR through 2 effects on pacemaker tissue:
1) Hyperpolarisation of the SA node membrane (takes longer to reach threshold)
2) 🔽 the rate of spontaneous depolarisation
ACh increases K+ permeability by…
slowing the closure of K+ channels
PS stimulation ________ (🔼/🔽) the AV node’s excitability which _________ (prolongs/shortens) transmission of impulses to the ventricles
🔽
prolongs
PS stimulation ________ (shortens/elongates) the plateau phase of the AP in atrial contractile cells, _________ (weakening/strengthening) atrial contraction
shortens
weakening
PS stimulation has _____ (no/little/big) effect on ventricular contraction
little
overall, PS stimulation causes:
- _______ HR
- _______ time between atrial and ventricular contraction
- _______ (stronger/weaker) atrial contraction
🔽
🔼
weaker
SNS’s main effect on the ❤️ is to ______ (speed up/slow down) depolarisation, so threshold is reached more _______ (rapidly/slowly)
speed up
rapidly
NorAd auguments ____ and ____ channel activity
If (lower case ‘f’; funny current)
T-type
SNS stimulation of the AV node _____ (🔼/🔽) AV nodal delay by ______ (🔼/🔽) conduction velocity
🔽
🔼
SNS _____ (speeds up/slows down) the spread of the AP throughout the specialised conduction pathway
speeds up
SNS _____ (🔼/🔽) contractile strength of the atrial and ventricular contractile cells (heart beats _______ (more/less forcefully) and squeezes out _____ (less/more) blood)
🔼
more forcefully
more
SNS _____ (🔼/🔽) Ca2+ permeability through prolonged opening of _________ channels
🔼
L-type Ca2+
SNS ________ (speeds up/slows down) relaxation
speeds up
The overall effect of SNS stimulation on the ❤️ is to improve its effectiveness as a pump by:
__ (🔼/🔽) HR
__ (🔼/🔽) the delay between atrial and ventricular contraction
__ (🔼/🔽) conduction time through the heart
__ (🔼/🔽) the force of contraction
__ (⏮/⏭) the relaxation process so that more
time is available for filling
🔼 HR 🔽 the delay 🔽 conduction time 🔼 the force ⏭ (speeding up) the relaxation process
under resting conditions _____ (PS/S) discharge dominates = vagal tone (___ - ___ bpm)
PS (parasympathetic)
~70 - ~100 bpm
HR can be altered by shifting the balance of AN stimulation:
- HR 🔼 by simultaneously 🔼 ___ and 🔽 ___ activity
- HR 🔽 by simultaneously 🔼 ___ and 🔽 ___ activity
S; PS
PS; S
Activity of the autonomic nervous system is co-ordinated by the ________________, located in the brain stem
cardiovascular control centre
The hormone ___________ also exerts an important influence in HR regulation
adrenaline (epinephrine)
Adrenaline is released into blood in response to ____________
sympathetic stimulation
Hormone adrenaline and noradrenaline (______) 🔼 HR (_______) and force of myocardial contraction (_______)
catecholamines
chronotropic action
inotropic action
Adr acts on ❤️ in a ______ (different/similar) manner to NorAd to ____ (🔼/🔽) HR
similar
🔼
Adrenaline ______ (lessens/reinforces) the direct effect of the sympathetic nervous system
reinforces
The pacemaker potential is regulated by a depolarizing current the ‘funny current’ (If) mediated by channels that are activated by:
(i) ________ and
(ii) ________
hyperpolarization
cyclic AMP
cyclic AMP are also known as HCN channels
what does the HCN channel stand for?
Hyperpolarization-activated Cyclic Nucleotide gated channel
Hyperpolarization following the action potential activates ___ channels in the ___ node causing a ____ (fast/slow) depolarization aka the pacemaker potential
HCN
SA
slow
for full text see p. 83
Block of HCN channels ______ (🔼/🔽) the slope of the pacemaker potential and ______ (🔼/🔽) heart rate
🔽 [decreases]
🔽 [reduces]
________ is a selective blocker of HCN channels that is used to _____ (🔼/🔽) heart rate in angina
_____ (🔼/🔽) rate ______ (🔼/🔽) O2 consumption
Ivabradine
🔽
🔽
🔽
angina
a condition in which coronary artery disease reduces the blood supply to cardiac muscle
β-adenoreceptor agonists (3)
Dobutamine, adrenaline and noradrenaline (catecholamines)
Pharmacodynamic effects of β-adenoreceptor agonists on ❤️:
___ (🔼/🔽) force, rate and cardiac output (i.e. HR x SV) and O2 consumption
___ (🔼/🔽) cardiac efficiency (O2 consumption___ (🔼/🔽) more than cardiac work)
____ (✅/❌) cause disturbances in cardiac rhythm (arrhythmias)
🔼
🔽
✅
clinical uses of adrenaline (3)
- cardiac arrest
- emergency treatment of asthma
- anaphylactic shock
clinical uses of dobutamine (1)
(selective for 1-adrenoceptors)
acute, but potentially reversible, heart failure (e.g. following cardiac surgery, or cardiogenic shock)
cardiac arrest
sudden loss of pumping function
anaphylactic shock
life threatening respiratory distress and often vascular collapse