𝑇𝑒𝑡𝑟𝑎𝑐𝑦𝑐𝑙𝑖𝑛𝑒

Question 1

Source

Answer 1

Natural, Semisynthetic

Question 2

Members Low to Moderate lipid solubility:

Answer 2

Tetracyclinin
Demeclocycline

Question 3

High lipid solubility members

Answer 3

Minocycline
Doxycycline.

Question 4

Low to Moderate lipid solubility absorption

Answer 4

Incomplete oral

Question 5

High lipid solubility

Answer 5

Completely absorbed orally

Question 6

Absorption is reduced by

Answer 6

Milk, Ca+2, Mg+2, Fe+2 & Al+3

Question 7

Distributed

Answer 7

Pass BBB & Placental barriers.

Question 8

Pharmacokinetics:

Answer 8

Available for Oral, IM, IV, Eye Drops & Ointment

Question 9

Metabolism

Answer 9

Liver

Question 10

Excretion

Answer 10

urine, bile and milk

Question 11

Excretion of Doxycycline

Answer 11

feces

Question 12

Action on bacteria

Answer 12

Bacteriostatic.

Question 13

Mechanism of Action:

Answer 13

Binds to 30 S ribosomal subunits that inhibit access of the amino acyl-tRNA to mRNA-Ribosomal finally inhibit Protein synthesis.

Question 14

Indications

Answer 14

Demeclocycline is useful in chronic hyponatremia due to Syndrome of Inappropriate ADH secretion
(SIADH)

Question 15

Adverse effects

Answer 15

1. Teeth & Bone Abnormalities
   Teeth : Permanent yellow-brown discoloration
   Bone : Deformity & inhibition of growth
2. Teratogenicit
3. Inhibition of intestinal flora->superinfection
   4-Nephrotoxic
   5-hypersensitivity
   6-Minocycline -> vertigo

Question 16

Contraindications

Answer 16

1. Pregnancy
   2.lactation
   3.early childhood