分生重點 Flashcards

1
Q

Avery延續格里夫茲

發現

A

某物質為DNA

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2
Q

原核
真核複製時
複製單位幾個

A

真核多個

原核一個

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3
Q

內切酶

A

據專一性

限制酶屬之

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4
Q

原核的DNA POLYMERASE I

原核的DNA POLYMERASE III

A

I負責移除PRIMER

(具修復與校正能力)

III負責複製
III負責複製
III負責複製

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5
Q

真核的DNA POLYMERASE

A

Alpha primer
Gamma 粒線體
Delta+E 延滯股

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6
Q

Leading strand 程序

A
Helicase解旋
SSB結合
Primase作用
DNA Pol III作用
Topo解超螺旋
DNA pol I去除primer
(不需要ligase)
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7
Q

Lagging strand 程序

A
解旋
SSB結合
Primase
DNA Pol III
topo協助解超螺旋
DNA Pol I 去除primer 
Ligase接合
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8
Q

岡崎片段

A

DNA 一段+

RNA PRIMER一段

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9
Q

端粒酶

A

具有RNA模板
反轉錄活性
TTAGGG重複序列

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10
Q

切除型修補
利用____酶
切___股

A

剪除酶

單股

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11
Q

SOS 修補

___蛋白破壞___蛋白

A

RecA 蛋白

破壞 LexA蛋白

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12
Q

SnRNA後續功能

A

形成spliceosome

切除intron

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13
Q

SiRNA
__股
互補率__

A
雙股
互補率高
經Dicer切除 
形成RISC協助mRNA降解
可能和異染色質有關
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14
Q

miRNA
前驅物為__股
互補率高低不一定

A
前驅物單股
互補率可能略低
經Dicer切除
形成RISC 阻止轉譯 mRNA 
甚至促進降解
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15
Q

Antisense RNA

A

阻斷核糖體結合

不是促進降解!
不是促進降解!
不是促進降解!

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16
Q

Helix turn Helix

例子

A

Lac operon

Trp operon

17
Q

Helix loop helix

例子

A

免疫

Myo-D

18
Q

Transposon種類

人類DNA45%為此

A

SINE (Alu element) 10%
LINE 17%
Retroposon 17%

19
Q

反轉錄病毒之

Long terminal repeat 用途?

A

Enhancer

Promotor

20
Q

高度重複序列相關疾病

A

杭廷頓氏舞蹈症

脆弱X染色體症

21
Q

格里夫茲發現

A

S的某種物質讓R轉型

22
Q

DNA 雙股病毒

A
逼電線桿泡豆奶
B型肝炎
腺病毒(小感冒)
桿狀病毒(昆蟲)
皰疹病毒
痘病毒(天花)
乳突病毒
23
Q

雙股RNA

A

輪狀病毒

24
Q

正股RNA病毒

A

不攜外皇冠

布尼亞病毒 (漢他病毒)
細小RNA 病毒(腸病毒!)
外衣病毒 (德國麻疹)
黃熱病毒 (C肝、茲卡)
冠狀病毒 (SARS)
25
Q

負股RNA病毒

A

正負棒絲

正黏液
負黏液
棒狀病毒(Rhabdo) 狂犬病
絲狀病毒(Filovirus)伊波拉

26
Q

正股RNA

具反轉錄酶

A

HIV

HTLV-1(白血病)

27
Q

抑癌基因

A
P53
BRCA
XPD(著色性乾皮)
APC MCC DCC (CAM)
Rb
28
Q

Oncogene

A

Src
BCR-ABL
ras
Myc

29
Q

Lac operon 三個基因

A

Lac A transacetylase
Lac Y permease
Lac Z Beta-galactosidase

30
Q

CAP 功能

感受何者的濃度

A

感受cAMP量

31
Q

肽聚糖單體

A

NAM

NAG交替出現

32
Q

酸性氨基酸

A

Glutamate

Aspartate

33
Q

鹼性氨基酸

A

Arginine
Histidine
Lysine

34
Q

Na K PUMP抑制劑

A

烏本箭毒
岩沙海葵毒素(palytoxin)
Digoxin