—- Flashcards
1
Q
Antidepressants used in patients with epilepsy(with/without HTN)
A
Paroxetine ( almost all SSRIs are safe in HTN)
2
Q
Antidepressant that should be avoided in seizure
A
Bupropion
3
Q
Antidepressant for patients who are obese
A
Bupropion/Venlafaxine
4
Q
Drug of choice for epileptic patient who has loss of appetite
A
Mitrazapine
5
Q
Antidepressants act on which area in the brain
A
Post-synaptic
6
Q
Anxiolytic with least sedation and withdrawal symptoms
A
Bupropion
7
Q
Antidepressant used with cardiac patients
A
Sertraline
8
Q
Antidepressant, safe, in pregnancy
A
Sertraline
9
Q
Antidepressants safe in breastfeeding
A
Sertraline, paroxetine
10
Q
Secondary Tricyclic Antidepressants?
A
nortriptyline (is a metabolite of amitriptyline), protriptyline, and desipramine (is a metabolite of imipramine).
11
Q
Tertiary TCAs?
A
amitriptyline, imipramine, clomipramine, trimipramine, and doxepin.
12
Q
Nonselective MAO A-B Inhibitors
A
Phenelzine , Tranylcypromine , Isocratic
13
Q
Selective MAO A inhibitors
A
Moclobemide
14
Q
Selective MAO-B inhibitor
A
Rasgiline , Selegiline
15
Q
Washout period when switching from MAOIs to other antidepressants
A
2 weeks
16
Q
Drug used in case of sexual dysfunction developed after SSRIs
A
Bupropion
17
Q
Anxiety treatment
A
1st line : SSRIs
2nd line : Buspirone , TCAs
Others : propranolol, BZDs
18
Q
Typical Antipsychotics
A
Haloperidol , Chlorpromazine
19
Q
S.E of typical antipsychotics
A
Extrapyramidal side effects
Worsen negative symptoms
20
Q
Atypical Antipsychotics
A
Clozapine , Aripiprazole , Quetiapine , Olanzapine
21
Q
Clozapine S.E
A
Cause agranulocytosis
22
Q
DOC for patient with Tardive Dyskinesia
A
Valbenazin
23
Q
Meds for Extrapyramidal S.E
A
Benztropine , Diphenhydramine , BZDs
24
Q
Most effective in treating positive symptoms in schizophrenia
A
Atypical Antipsychotics ( 2nd generation )
25
Psychotic Patient taking olanzapine with high glucose. What is alternative?
Haloperidol ( less metabolic changes)
26
How does smoking affect clozapine and olanzapine
Increase metabolism, decrease medication concentration, increase clearance of medication
27
Acute mania treatment
Valproate or Lithium + Antipsychotic
28
Acute Bipolar treatment
Lithium or lamotrigine Also Lurasidone, Olanzapine / fluoxetine
29
Maintenance of mania
Lithium+/-2ndgenerationofAntipsychotic(SGA)
30
Maintenance of bipolar
Lamotrigine
31
Safe drugs for treatment of Bipolar disease in a pregnant woman
Lamotrigine , levetiracetam , lurasidone
32
Mood stabilizer?
Lithium
33
Side effects of lithium?
Tremor , GI , edema , hypothyroidism
34
Lithium effect on CrCl and BUN?
Decrease CrCl and increase BUN which cause renal impairment
35
Monitoring of lithium?
Monitor, renal and thyroid every 6 to 12 month
36
Treatment of convulsions due to lithium toxicity
Phenobarbital , propofol , BZDs
37
Lithium antidote?
Sodium polystyrene sulfonate NaHCO3
38
Why is carbidopa given with levodopa?
To prevent peripheral metabolism of levodopa
39
Mechanism of action of levodopa
Increase the dopamine level in brain leading to stimulate dopamine receptor
40
Dopamine receptor agonist ( in treatment of parkinson’s disease)
Pramipexole, Ropinirole, Apomorphine, Rotigotine
41
Amantadine uses?
Antiviral , Antiparkinsonian , Dopamine agonist
#cause Livedo reticularis ( شبكة تجلطات في القدمين )
42
Which anticholinergic is used in treatment of PD
Trihexyphenidyl
43
Treatment of nausea and vomiting in parkinson’s disease patients
Domperidone
44
Treatment of Psychosis in Parkinson’s disease patients
Quetiapine , primavanserin
45
Mild-moderate Alzheimer disease treatment
Donepezil , Rivastigmine , Glutamine
46
Advanced Alzheimer disease treatment
Donepezil
47
Dementia + Alzheimer disease treatment
Rivastigmine
48
BZDs used in Alzheimer ?
DACL
Diazepam
Alprazolam
Clonazepam
Lorazepam
49
Alzheimer patient with urinary urgency treatment
Oxybutynin
50
Moderate-severe Alzheimer treatment
Memantine +/- Donepezil
51
Anti-epileptic, safe in pregnancy
Levetiracetam , Lamotrigine
52
Anti-epileptic safe in breast-feeding
Levetiracetam
53
Which anti-epileptic require renal adjustment
Topiramate
54
Anti-epileptic used in absence seizures
Ethosuximide
55
Anti-epileptics used for elderly patients
Alprazolam , Oxazepam , Trizolam
56
Treatment of neuropathic, pain and depression
1st : Duloxetine , Pregabaline
Others ; Gabapentin , venlafaxine , BZDs
57
Side effects of Phenytoin
Gingival hyperplasia, nystagmus, hirsutism, acne, purple glove syndrome
58
ADHD Treatment
Atomixifin
59
Which vaccine cause autism
Thimerosal ( mercury) containing vaccines
60
Which all drugs dilate cervix
Oxytocin , Dinoprostone , Misoprostol
61
Safe HIV med for pregnancy/during labor
Zidovudine
62
Which drug stop premature labor?
Ritodrine
63
Treatment of preterm labor?
Magnesium sulfate , Indomethacin, Nifedipine
64
Treatment of Eclampsia
Mg sulfate
65
Drugs that induce abortion
Misoprostol, Mifepristone, Methotrexate
66
Which anti-estrogen causes abortion?
Anastrazole
67
Anti-progesterone causes abortion
Mifepristone, Misoprostol
68
Prevention and treatment of postpartum and post abortion hemorrhage?
Ergonovine
69
A Healthy mid age woman wants contraceptive which drug to give?
Ethinyl estradiol/ inestrenol (combination)
70
In which cases Ethinyl estradiol/ inestrenol (combination) is not given and what is the alternative contraceptive
35 + smoker or migraine headache or obese
• > 50
• Breastfeeding
• DM + Vascular disease
• Risk of DVT or history of
• Hx of uncontrolled HTN or heart problems
• Breast or endometrial cancer
• Need to get pregnant
Alternative is levonoregestrol
71
Which hormone the oral contraceptives suppress?
GnRH ( gonadotropine releasing hormone)
72
Oral contraceptives work on which phase of the cycle?
The ovulation phase
73
When taking Hydroxyurea contraceptive is required during and after how long? (Male and female)
Male 12 months
Female 6 months
74
Treatment of infertility in women who don’t ovulate?
Clomiphene citrate
75
Which hormone is predominant is the ovulation phase?
Luteinizing hormone
76
Which drug inhibits estrogen synthesis
Tamoxifen
77
Human chorionic gonadotropin is used for what?
Induce ovulation and treat infertility
78
Treatment of facial flushing and dry
Vagina
Estrogen
79
Isotretinon should be stopped before pregnancy by how long?
1 month
80
which drugs should be stopped before pregnancy by 2 months?
Neostigmine and Fingolimod
81
Ribavirin should be stopped before pregnancy by how long?
6 months
82
Leflunomide should be stopped before pregnancy by how long?
2 years
83
Mycophenolate should be stopped before pregnancy by how long ( answer for male and female)
Male 12 weeks
Female 6 weeks
84
Why is Ciprofloxacin contraindicated in pregnancy
Causes anemia of fetus if taken in the first semester
85
Why is nicotine and beta blockers contraindicated in pregnancy
Decrease blood flow to uterine
86
Why are ACE-Is are contraindicated in pregnancy
Effect fetal growth
87
Why is warfarin contraindicated in pregnancy?
Causes nasal bone, hypoplasia in neonate
88
Which drug/hormone causes genital malformations in infants if taken during pregnancy?
If the question ask about hormone answer is androgen
If they ask about drug answer is Finasteride
89
Why is Progesterone contraindicated during pregnancy
Causes fetal, productive abnormalities
90
Which anti-estrogen used in breast cancer 
Tamoxifen
91
Treatment of breast cancer
Raloxifen and Tamoxifen
92
Prophylaxis of breast cancer
Raloxifen
93
What are the early symptoms of breast cancer?
Dimples or nipple discharge
94
Which drug is safe to treat UTI during pregnancy
Nitrofurantoin
95
Pregnant with UTI+G6PD
Cefuroxime
96
Prevention of recurrence of UTI?
Trimethoprim-sulfamethoxazole (TMP/SMX)
97
Pregnant woman with vaginal itching and E.coli
Nirtofurantoin
98
Pregnant woman with pyelonephritis she’s been treated with IV ceftriaxone what is the most appropriate antibiotics
Amoxicillin/Clavulanate or Cefuroxime
99
Pregnant with Syphilis
Benzathine penicillin, Amox/Clavul
If she has allergy to Penicillin
Erythromycin , ceftriaxone
100
Breastfeeding with mastitis
Dicloxacillin , Cephalexin Amox/Clavul
If there’s penicillin allergy then
Clarithromycin
101
Pregnant with candida albicans
Clotrimazole
102
Anti-fungals contraindicated in pregnancy
Griseofulvin , Ketoconazole , Voriconazole
103
Anti-fungals safe in pregnancy
Amphotericin B , Topical imidazole , Nystatin
104
Antifungals contraindicated in lactation
Ketoconazole , Itraconazole , Voriconazole
105
Antifungal, safe in lactation
Fluconazole
106
Pregnant with tonic clonic seizure
Valproic acid + folic acid
107
Pregnant with schizophrenia
Olanzapine , Risperidone , Quetiapine
108
Laxatives contraindicated in pregnancy
Senna and castor oil
109
Treatment of constipation in pregnancy
Psyllium , glycerin suppositories or lactulose
110
Nausea with or without vomiting in pregnancy
Vit B6 +/- Doxylamine
111
Gastroesophageal reflux treatment in pregnancy
Calcium carbonate antacid
112
Which anticoagulants are safe to use in pregnancy
Low molecular weight heparin
113
Treatment of asthma in pregnancy
Albuterol, Cromolyn
114
Treatment of glaucoma in pregnancy
Brimonidine or timolol
115
Treatment of hyperthyroidism in pregnancy
1st PTU (Propylthiouracil)
2nd methimazole
116
Pregnant with Diabetes
1st insulin
2nd metformin, Glyburide
117
Pregnant with hypertension
Methyldopa Labetolol Nifedipine
118
DOC for emergency and urgency hypertension in pregnancy
Hydralazine
119
Which bacteria is responsible for milk, production in women
Lactobacillus
120
1st baby milk is called?
Colostrum
121
Which medications increase prolactin levels
Metoclopramide Methyldopa , Estradiol
Serotonin, GABA, Opioids
122
Which medication decreased prolactin levels
Bromocriptine , Cabergoline
123
Which immunoglobulin crosses placenta
IgG
124
Which is the largest immunoglobulin
IgM
125
Which is the immunoglobulin found in anaphylaxis, asthma, allergy, and hypersensitivity
IgE
126
Which immunoglobulin found in infection disease
IgM
