Zoonoses Flashcards

1
Q

What is the WHO definition of a zoonoses?

A

Infections that are naturally transmitted between vertebrate animals and humans

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2
Q

Where is source of disease in zoonoses?

A

Animals

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3
Q

What are NOT zoonoses and why?

A

Malaria
Schistosomiasis
Oncoceriasis
Elephantiasis

Transmitted by animals, but depend on the human host for part of their life-cycle

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4
Q

What are anthroponosis?

A

An infectious disease in which a disease causing agent carried by humans is transferred to other animals

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5
Q

What are examples of anthroponosis?

A

Influenza
Strep throat
Leishmaniasis
Chytridiomycosis

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6
Q

What can zoonoses by caused by?

A

Virus, bacteria, parasites or fungi

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7
Q

What are examples of bacterial zoonoses?

A
Salmonella
Campylobacter
Shigella
Anthrax
Brucella
E.coli
Leptospirosis
Plague
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8
Q

What are examples of zoonotic viruses?

A
Rabies
Avian flu
Crimean-Congo haemorrhage fever (CCHF
Ebola
Laa fever
West Nile fever
Yellow fever
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9
Q

What are examples of parasitic zoonoses?

A
Cysticercosis
Echinococcosis
Toxoplasmosis
Trichinellosis
Visceral larva migrans
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10
Q

What are examples of fungal zoonoses?

A

Dermatophytoses

Sporotichosis

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11
Q

What are the most common zoonoses in the UK?

A

Salmonella
Campylobacter
Toxoplasma
Ringworm/dermatophytosis

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12
Q

What are rare zoonoses for the UK?

A

Anthrax
Rabies
Bubonic plague

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13
Q

What are emerging zoonoses?

A

A zoonosis that is newly recognised or newly evolved, or that has occurred previously but shows an increase in incidence or expansion in geographical, host or vector range

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14
Q

What is rabies?

A

A viral infection transmitted from bite of infected animal

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15
Q

What are the main transmitters of rabies?

A

Dogs, bats, monkeys

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16
Q

What is the incubation period in humans for rabies?

A

2 weeks to several months

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17
Q

What does rabies do once in the body?

A

Travels to the brain via peripheral nerves and causes acute encephalitis

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18
Q

What are the signs/symptoms of rabies?

A
Malaise, headache, fever
Progressing to mania, lethargy & coma
Over production of salvia & tears
Unable to swallow & hydrophobia
Death by respiratory failure
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19
Q

How is diagnosis of rabies made?

A

PCR of saliva or CSF

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20
Q

What is the prognosis of rabies if untreated?

A

Fatal

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21
Q

What is the management for rabies?

A

Post-exposure prophylaxis
Human rabies immunoglobulin (HRI)
+4 doses rabies vaccine over 14 days

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22
Q

What is brucellosis?

A

Highly contagious zoonosis caused by ingestion of unpasteurized milk or undercooked meat from infected animals, or close contact with their secretions

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23
Q

What did brucellosis used to be an occupational hazard of?

A

Farmers, vets, slaughterhouses

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24
Q

How are the organisms excreted in brucellosis?

A

In milk, placenta and aborted foetus

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25
Q

How are humans infected by brucellosis?

A

During milking
During parturition
Handing carcasses
Consumption unpasteurised dairy products

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26
Q

What are the 3 species of brucella?

A

Melitensis
Suis
Abortus

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27
Q

What is the incubation period for brucellosis?

A

5-30 days (up to 6mo)

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28
Q

What are the 4 types of symptoms of brucellosis?

A

Acute
Subacute
Chronic
Subclincal (commonest)

29
Q

What is the acute presentation of brucellosis and how does it typically last?

A
High undulant fever
Weakness, headaches
Drenching sweats
Splenomegaly
Lasts 1-3wks
30
Q

What is the subacute presentation of brucellosis and how does it typically last?

A

Fever and joint pains

Lasts over 1mo

31
Q

What is the chronic presentation of brucellosis and how does it typically last?

A
Flu-lie symptoms
Malaise
Depression
Chronic arthritis
Endocarditis
Splenomegaly
Epididymo-orchitis
Lasts for months-years
32
Q

What is the most common form of symptom presentation in brucellosis?

A

Subclinical

33
Q

What is the treatment for brucellosis?

A

Long acing doxycycline for 2-3mo + rifampicin + IM gentamicin for 1st week

34
Q

If CNS disease in brucellosis, what treatment should you add?

A

Cotrimoxazole for 2wks

35
Q

What bacteria used to cause leptospirosis in fisherman and miners?

A

Leptospira icterohaemorrhagica

36
Q

What is the common form of leptospirosis now?

A

Leptospira hardjo

37
Q

What is leptospirosis caused by today?

A

Cattle

38
Q

What are the signs/symptoms of leptospirosis today?

A

Fever
Meningism: headaches
Myalgia
Abdo pain

39
Q

How does leptospirosis penetrate host?

A

Abraded skin or mucous membranes and cause systemic illness

40
Q

What type of bacteria are leptospirosis?

A

Spirochaetes

41
Q

What is the incubation period for leptospirosis?

A

2-30 days

42
Q

How is leptospirosis transmitted to human host?

A

Direct contact with animal

Contact with environment (water) contaminated with urine

43
Q

What happens in severe leptospirosis?

A

Weil’s disease: triad jaundice, AKI, bleeding

Pulmonary haemorrhage

44
Q

What is Weil’s disease?

A

Severe form of leptospirosis

45
Q

What are the investigations for leptospirosis?

A

Microscopic agglutination test (MAT)
ELISA serology
PCR
Culture

46
Q

What is the treatment for leptospirosis?

A
Antibiotics
Doxycline: mild
IV penicillin: severe
Dialysis
Mechanical ventilation
47
Q

How is lyme borrelios transmitted?

A

Ticks: I.ricinus

48
Q

When are ticks most active (Lyme disease)?

A

> 4’C

Humidity

49
Q

What is a sign of Lyme disease in 80-90% cases?

A

Erythema migrans

50
Q

What is the diagnosis for Lyme disease?

A

Clinical diagnosis
Erythema migrans
Single or multiple lesions

51
Q

How soon after the bike does erythema migrans usually present in Lyme disease?

A

3-90 days

52
Q

What are presentations of Lyme disease?

A
Erythema migrans
Acrodermatitis chronica atroficans
Lymphocytoma
Neuroborreliosis
Cardiac disorders: carditis, heart block
Arthritis
53
Q

How does acrodermatitis chronica atroficans (ACA) present in Lyme disease?

A

Bluish-red discolouration on extensor surfaces of distal extremities
Progresses over months to years to atrophic phase

54
Q

What is common in acrodermatitis chronica atroficans (ACA)?

A

Peripheral neuropathy

55
Q

How does lymphocytoma present in Lyme disease?

A

Bluish solitary painless nodule

Usually earlobe or areola

56
Q

How does neuroborreliosis present in Lyme disease?

A

Triad of facial nerve palsy, radicular pain & lymphocytic meningitis

57
Q

What is the triad that presents in neuroborreliosis?

A

Facial nerve palsy
Radicular pain
Lymphocytic meningitis

58
Q

When does the onset of neuroborreliosis symptoms present in Lyme disease?

A

2-6 wks after bite

59
Q

What are more common presentations in Lyme disease in the US?

A

Cardiac disorders: carditis/heart block

Arthritis

60
Q

How is Lyme disease diagnosed?

A

EM = clinical diagnosis
ACA & lymphocytoma = clinical and serology
Arthritis = serology/PCR from synovial fluid
NB = clinical and lab

61
Q

What is the treatment for Lyme disease?

A

Antibiotics:

Oral doxycycline or amoxicillin or IV ceftriaxone for 21 days

62
Q

What is Q-fever?

A

Bacterial infection caused by the bacteria Coxiella burnetii. The bacteria are most commonly found in cattle, sheep, and goats around the world. Humans typically get Q fever when they breathe in dust that was contaminated by infected animals

63
Q

What are the clinical features of Q-fever?

A
Q fever does not always cause symptoms. Some people get flu-like symptoms within 2 to 3 weeks of being infected, such as:
a high temperature (fever)
aching muscles
tiredness
feeling sick
a sore throat
swollen glands
Symptoms of Q fever usually last up to 2 weeks.
64
Q

What is the management for Q-fever?

A

Antibiotics

65
Q

What is toxoplasmosis?

A

A disease from infection with the Toxoplasma gondii parasite, one of the world’s most common parasites. Infection usually occurs by eating undercooked contaminated meat, exposure from infected cat feces, or mother-to-child transmission during pregnancy.

66
Q

What are the signs/symptoms of toxoplasmosis?

A

Toxoplasmosis doesn’t usually cause any symptoms and most people don’t realise they have had it.
Some people get flu-like symptoms, such as:
high temperature (fever)
aching muscles
tiredness
feeling sick
sore throat
swollen glands
If you do have symptoms, they normally get better on their own within about 6 weeks.

67
Q

What is psittacosis?

A

A zoonotic infectious disease in humans caused by a bacterium called Chlamydia psittaci and contracted from infected parrots, such as macaws, cockatiels, and budgerigars, and from pigeons, sparrows, ducks, hens, gulls and many other species of birds.

68
Q

What are the signs/symptoms of psittacosis?

A

Acute respiratory disease
Flu-like symptoms
Severe pneumonia

69
Q

What is the treatment for psittacosis?

A

Antibiotics