Zofran (Ondansetron Hydrochloride)

Question 1

Classification

Answer 1

Antiemetic

Question 2

Mechanism of Action

Answer 2

• Selective 5-HT3 receptor antagonist

Question 3

Indications

Answer 3

• Profound nausea & vomiting in patients over 12 years of age

Question 4

Contraindications

Answer 4

• Hypersensitivity
• Hypotension
• Altered LOC/coma
• Patients with compromised respiratory function (COPD, acute asthma attack, sleep apnea)

Question 5

Adverse Effects

Answer 5

• Drowsiness
• Extrapyramidal reactions (dystonia, oculogyric, akathisia-motor restlessness)
• Hyper/hypotension
• Decreased seizure threshold
• Respiratory depression

Question 6

Administration

Answer 6

• 4 mg IV or IM slowly over 2-5 minutes

Question 7

Notes

Answer 7

• Should not be taken with MAO (mono-amine oxidase) inhibitor class of antidepressants such as Marplan, Nardil, Parnate, or Matulane, since the effects of both drugs add to each other and lead to complications
• Avoid exposure of the medication to sunlight