Z drugs

Question 1

Zolpidem dose insomnia short term use

Answer 1

10mg daily for up to 4 weeks, at bed

debilitated or elderly 5mg OD for up to 4 weeks at bedtime

Question 2

CI zolpidem

Answer 2

Acute respiratory depression; marked neuromuscular respiratory weakness; myasthenia gravis; obstructive sleep apnoea; psychotic illness; severe respiratory depression

Question 3

all interactions are to do with …

Answer 3

sedation

Question 4

is anterograde amnesia a common side effect of zolpidem

Answer 4

yes

Question 5

zolpidem use in pregnancy

Answer 5

Avoid regular use (risk of neonatal withdrawal symptoms); high doses during late pregnancy or labour may cause neonatal hypothermia, hypotonia, and respiratory depression.

Question 6

zolpidem use in BF

Answer 6

Small amounts present in milk—avoid.

Question 7

driving and skilled tasks & how long to leave between taking zolpidem and performing

Answer 7

Drowsiness may persist the next day—leave at least 8 hours between taking zolpidem and performing skilled tasks (e.g. driving, or operating machinery); effects of alcohol and other CNS depressants enhanced.

Question 8

zopiclone dose insomnia short term use

Answer 8

7.5mg OD for up to 4 weeks at bed time

elderly initially 3.75mg OD for up to 4 weeks at bed time, may be increased if necessary to 7.5mg OD

Question 9

contraindications zopiclone

Answer 9

Marked neuromuscular respiratory weakness; myasthenia gravis; respiratory failure; severe sleep apnoea syndrome

Question 10

common SE zopicolone

Answer 10

dry mouth
bitter taste

Question 11

zopiclone in pregnancy

Answer 11

Not recommended (risk of neonatal withdrawal symptoms).

Use during late pregnancy or labour may cause neonatal hypothermia, hypotonia, and respiratory depression.

Question 12

zopiclone in BF

Answer 12

present in milk avoid