narcolepsy

Question 1

what is nacrolepsy

Answer 1

chronic neurological disorder that affects the brains ability to control sleep wake cycle

Question 2

symptoms of narcolepsy

Answer 2

feeling rested after waking, but then feeling very sleepy throughout most the day
hallucinations
excessive daytime sleepiness
sleep paralysis
sleep disruption

Question 3

non drug advice on narcolepsy management

Answer 3

• take frequent, brief naps evenly throughout the day
• stick to strict bedtime routine
• relax before going to bed e.g. warm bath
• good sleeping environment e.g. free from distractions, quiet, comfortable temp
• avoid caffeine, alcohol, smoking before bed
• do not exercise too close to bedtime (2 hr gap)
• do not eat large heavy meals

Question 4

should you advice patients with narcolepsy to exercise before bedtime to help them make it easier to sleep at night

Answer 4

no, ensure 2 hour gap between finishing exercise and going to bed

Question 5

name 3 CNS stimulants used in treatment of narcolepsy & how do they work & when are they taken

Answer 5

modafinil
pitolisant
solriamfetol

they stimulate the CNS, which can help you keep awake during the day
usually taken in every morning

Question 6

name a CNS depressant used in treatment of narcolepsy with cataplexy (under expert supervision)

Answer 6

sodium oxybate

Question 7

what is cataplexy

Answer 7

sudden loss of muscle tone while a person is awake leads to weakness and a loss of voluntary muscle control

Question 8

pre treatment screening and monitoring for modafinil

Answer 8

pre treatment screening: ECG required before initiation
monitoring: BP and HR in hypertensive pt

Question 9

Can you use modafinil in pregnancy

Answer 9

MHRA advice - avoid
increased risk of congenital malformations