YFV Flashcards
1
Q
What viral family does YFV belong to?
A
Flavivirdae…like HCV and HGV
2
Q
What kind of genome does YFV have?
A
Non-segmented +ssRNA
5’cap
3
Q
What is the outermost layer of YFV?
A
E1 and E2 glycoproteins
4
Q
How is YFV spread?
A
Aedes mosquitos
5
Q
Is YFV cytolytic?
A
Yes…serious systemic disease
6
Q
What kind of immune response is caused by YFV infection?
A
Both humoral and cellular…resulting inflammation causes tissue destruction
7
Q
What are the symptoms to a YFV infection?
A
Severe systemic disease
Flu-like syndrome (GI hemorrhages –> black vomit)
Loss of liver, kidney, and/or heart function
Hemorrhagic fever
Shock
Death (50%)
8
Q
How is YFV diagnosed?
A
Immunoflorescence RT-PCR ELISA Various serologies Direct isolation of the virus
9
Q
How is YFV treated?
A
Supportive care
Vector control measures
10
Q
What kind of vaccine is there for YFV?
A
Live-attenuated vaccine
