XVII - The Pancreas Flashcards
This disease is characterized by the following morphological changes:(1) microvascular leakage causing edema, (2) necrosis of fat by lipases, (3) an acute inflammatory reaction, (4) proteolytic destruction of parenchyma,(5) destruction of blood
Acute pancreatitis (TOPNOTCH) Robbins Basic Pathology, 8th ed., pg. 677
Cardinal manifestation of acute pancreatitis
Abdominal pain(TOPNOTCH)Robbins Basic Pathology, 8th ed., pg. 679
Necrosis of pancreatic tissue affecting acinar and ductal tissues as well as the islets of Langerhans; vascular damage causes hemorrhage into the parenchyma.
Acute necrotizing pancreatitis(TOPNOTCH)Robbins Basic Pathology, 8th ed., pg. 678
Characterized by parenchymal fibrosis, reduced number and size of acini, and variable dilation of the pancreatic ducts. With relative sparing of Islets of Langerhans. Ductal concretions are present
Chronic pancreatitis(TOPNOTCH)Robbins Basic Pathology, 8th ed., pg. 680
Presents as painless, slow-growing cystic masses filled with thick, tenacious mucin, lined with columnar mucinous epithelium, associated with densely cellular stroma. Almost always arise in women
Mucinous cystic neoplasm of the pancreas(TOPNOTCH)Robbins Basic Pathology, 8th ed., pg. 681
Similar to mucinous cystic neoplasms but appear more frequently in men
Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas(TOPNOTCH)Robbins Basic Pathology, 8th ed., pg. 682
Most common location of pancreatic cancer.
Head of pancreas(TOPNOTCH)Robbins Basic Pathology, 8th ed., p. 684
Most common symptom of pancreatic carcinoma located at the tail and body of the gland?
None/AsymptomaticSince it does not impinge on the biliary tract, it may be quite large and widely disseminated by the time they are discovered.(TOPNOTCH)Robbins Basic Pathology, 8th ed., p. 684
Moderately to poorly differentiated adenocarcinoma forming abortive tubular structures or cell clusters and exhibiting an aggressive, deeply infiltrative growth pattern.
Pancreatic carcinoma(TOPNOTCH)Robbins Basic Pathology, 8th ed., p. 684
Type of pancreatic carcinoma showing prominent acinar cell differentiation with zymogen granules and exocrine enzyme production
Acinar cell carcinomas(TOPNOTCH)Robbins Basic Pathology, 8th ed., p. 684
Type of pancreatic carcinoma with focal squamous differentiation in addition to glandular differentiation.
Adenosquamous carcinomas(TOPNOTCH)Robbins Basic Pathology, 8th ed., p. 684
What is the most common clinically significant congenital anomaly of the pancreas?
Pancreas Divisum(TOPNOTCH)
This congenital abnormality develops embryologically when one portion of the ventral pancreatic primordium becomes fixed, while the other portion of this primordium is drawn around the duodenum
Annular Pancreas(TOPNOTCH)
The most common cause of acute pancreatitis is?
Excessive alcohol intake(TOPNOTCH)
5 morphological alterations in Acute pancreatitis
- Edema caused by microvascular leakage2. Necrosis of fat caused by lipolytic enzymes3. Acute inflammatory reaction4. Destruction of pancreatic parenchyma by proteolytiz enzymes5. Destruction of blood vessels with subsequent interstitial hemorrage(TOPNOTCH)
The most common cause of chronic pancreatitis is?
Long term alcohol abuse(TOPNOTCH)