X-linked Recessive Disorders

Question 1

What patterns of inheritance do X-linked recessive disorders carry?

Answer 1

MALES affected, females are carriers. If any females in the past had something then it is NOT x-linked recessive.

Associated with ENZYME DEFICIENCIES.

Question 2

Hemophilia A/B

Answer 2

X-linked recessive

Factor 8 and 9 enzyme deficiencies

Question 3

G6PD

Answer 3

X-linked recessive

Question 4

Chronic Granulomatous Disease

Answer 4

X-linked recessive

Enzyme deficiency of breaking down bacterial cells inside neutrophils

Question 5

Duchenne Muscular Dystrophy

Answer 5

X-linked recessive, Enzyme deficiency

Question 6

Nephrogenic DI

Answer 6

X-linked recessive, Enzyme deficiency

Question 7

Retinitis Pigmentosa

Answer 7

X-linked recessive, Enzyme deficiency

Question 8

Androgen Insensitivity

Answer 8

X-linked recessive, Enzyme deficiency

Phenotypically female, but genetically male

Question 9

Wiskott Aldrich Syndrome

Answer 9

X-linked recessive, Enzyme deficiency

Question 10

Hunter syndrome

Answer 10

X-linked recessive, Enzyme deficiency

Question 11

For x-linked recessive disorders what are:

1. changes of having an affected male child
2. changes of having and affected child

Answer 11

Males
50% will be affected
50% will NOT be affected

Females
50% will be carriers
50% will NOT be carriers

Children
25% will be carriers
25% will have the disease
50% will be NORMAL