Wounds Flashcards
Transepithelial Potential Difference
Healthy (intact) skin carriers a slightly negative charge
(Average skin potential -23.4 mV)
What occurs when skin is damaged?
an influx of (+) ions (Na+) interacts with (Cl-) which leads to a low-level bioelectric signal = current of injury
Current of Injury
- Negative chloride is typically sitting on top of the skin
- If you get it into the dermis, it is goes to shoot sodium up (+)
- This is what signals the derived platelet factors, which bring the so on and so on
What does a wound create?
- a low resistance pathway in which transepithelial potential (voltage) drives current out of the wound
- All types of tissue
- Disruption of these currents alters normal development, regeneration and wound healing
Injury current –> Role of E stim
- a moist wound environment is needed for the bioelectric system to function
- Dry tissue (necrosis) and infection can block these bioelectric signals thus disrupting the signals for repair process
Electrotaxis/Galvanotaxis
- Directional migration of cells in an electric
field - Some cells in the substratum migrate actively
to a specific pole
Which cells will migrate in an electric field
epithelial cells, neutrophils, macrophages, fibroblasts, endothelial cells, and nerve cells
Charge
– When an electrically neutral atom is acted upon by an outside force lending to loss or gain of electrons
– Measured in coulomb
Charge Density
Electrical charge per unit of cross-sectional area
Conductive Coupling
Electrical currents delivered directly or through a
pulsed electromagnetic field (PEMF)
what is a good conductive medium for superficial or small wounds
hydrogel
what should you use as a conductive medium for larger wounds
moisten the gauze with saline and pack the wound
Currents for wound healing
- Capacitive Coupled Electrical Currents (CCEC)
- Low Intensity Currents (LIC)
- Low intensity Direct Current (LIDC)
- Microcurrents (MC)
HVPC and LVPC
Phases of Healing
Inflammatory
Proliferative
Epithelialization
Maturation/Remodeling
Inflammatory Phase
- Initiates the wound repair process by its effect on the current of injury
- Neutrophils and macrophages both have a negative charge
- increases blood flow
- Promotes phagocytosis
- Enhances tissue oxygenation
- Reduces edema perhaps from reduced microvascular leakage