Wound healing, Regeneration And Repair

Question 1

Stimulus of wound healing

Answer 1

Tissue injury

Question 2

Phases of wound healing

Answer 2

Inflammation
Proliferation
Remodeling

Question 3

Coagulation in tissue injury is mediated by what factors

Answer 3

Platelets
PDGF
TGFb
TGFa
EGF

Question 4

What activates clotting cascade and inflammatory phase

Answer 4

Exposed tissue collagen

Question 5

What concentrates cytokines and growth factors

Answer 5

Fibrin clots

Question 6

In the first 48hrs, what phagocytose

Answer 6

Granulocytes

Question 7

What arrives after 24hrs

Answer 7

Monocytes

Question 8

Cytokines for angiogenesis

Answer 8

FGF
PDGF
TGF
TNFa

Question 9

Hemostasis and inflammation occurs over

Answer 9

Days 4-6

Question 10

Covering of wound with epithelium occurs between days

Answer 10

4-14

Question 11

Production of collagen by migrating fibroblasts occurs in

Answer 11

Days7 - 6th week

Question 12

What at the wound margin, flatten and migrate into the open wound

Answer 12

Basal keratinocytes

Question 13

What causes contraction with pulling of the wound edges towards the center

Answer 13

Myofibroblast

Question 14

The tensil strength remains about

Answer 14

80% of the original

Question 15

Which of the wounds heal with minimal scar

Answer 15

Healing by first intention(surgery)

Question 16

Local factors affecting wound healing

Answer 16

Infection
Foreign bodies
Mechanical factors such as excessive movement 
Size,location and type of wound
Oedema
Ischemia
Ionizing radiation

Question 17

Systemic factors affecting wound healing

Answer 17

Age
Nutrition
Metabolic status
Circulatory “
Hormonal drugs
Connective tissue disorder
Smoking

Question 18

Weak scar tissue is due to

Answer 18

Deficient collagen formation

Question 19

Contractures occurs in a wound that

Answer 19

Spans a joint