Wound healing

Question 1

? (immediate);
Platelets aggregate at the site in response to exposed collagen, releasing
inflammatory markers and activate clotting & complement cascades.
? is then achieved by ? and ? formation.

Answer 1

haemostasis x2
vasospasm
thrombus

Question 2

? (0-3 days);
Vasodilatation and increased capillary permeability allow inflammatory cells
to enter the wound, leading to ?.
? enter the tissues to debride and kill bacteria, followed by ? to phagocytose the debris and orchestrate fibroblast migration.

Answer 2

inflam
oedema
neutrophils
macrophages

Question 3

? (3 days - ? weeks);
? migrate in to synthesise collagen, with myofibroblasts secreting actin-containing products to cause wound ?.
? is stimulated by hypoxia, and also the ? secreted by neutrophils and macrophages. This creates granulation tissue.

Answer 3

proliferation
fibroblasts
contraction
angiogenesis
cytokines

Question 4

? (? weeks to 1 year);

Re-orientation and maturation of ? fibres to increase wound ?.

Answer 4

remodelling
collagen
strength

Question 5

Epithelialisation;
- The covering of a denuded surface (? ? removed) with epithelial tissue, occurring from the ? ? of the wound after granulation.

Answer 5

skin surface

outer edges

Question 6

Primary Intention Healing

Takes place where there is a close apposition of ? wound edges·
o ? in cut blood vessels prevents ? formation.
o Coagulated blood forms a surface ? to keep the wound ?.

Answer 6

clean
thrombosis
haematoma
scab
clean

Question 7

Primary Intention Healing

o ? is able to form a weak framework between the edges, over which ?proliferate and secrete ? into the ?network.
o The ? network of the dermis cannot be replaced.

Answer 7

fibrin
capillaries
collagen
fibrin
elastic

Question 8

Secondary Intention Healing

Takes place in wounds where the skin edges cannot be clearly ?;
o Phagocytosis removes ?, and ? tissue forms to fill the defect.
o ? regeneration then covers the surface

Answer 8

opposed
debris
granulation
epithelial

Question 9

There is greater loss of tissue in ? intention healing.

Factors that affect wound healing are ?, ?, ?, ?, ??? levels, ? and other inflammatory conditions such as ?.

Answer 9

age diabetes nutrition smoking HGH infection RA