Wound Healing Flashcards
What is primary wound healing?
Healing by primary intention:
-Tissue is anatomically re-approximated
Advantages of primary wound healing?
- Easier care
- Faster return of function
- Better cosmetically
Disadvantages of primary wound healing?
Increased risk of infection
What is secondary wound healing?
By secondary intention:
-Wound left open; granulation tissue forms and wound closes by contraction of tissues
Advantages of secondary wound healing?
Infection is nearly impossible
-Good for highly contaminated wounds
Disadvantages of secondary wound healing?
Complicated care
Possible poor cosmetic outcome
What is tertiary wound healing?
Delayed primary closure:
- Wound left open for 5 days w/ wound care then surgically closed
- Abundant granulation tissue-vascular
- Rarely used
How long is inflammatory phase in primary wound healing?
4 days
-Unknown in secondary or tertiary
How long is the maturation and remodeling phase in wound healing?
9-12 months
When does the proliferative phase in wound healing occur?
After epithelium covers wound
Can a chronic wound be converted to an acute wound?
Yes
Do we use systemic ABX for an infected wound?
No, only if there is sepsis or cellulitis
What can inhibit wound healing?
Edema
Pressure
What vitamin is important for collagen production?
Folic acid
What is magnesium important for in wound healing?
Protein synthesis
What role does vitamin A play in wound healing?
Inflammatory response
Macrophages
Collagen
What role does Zinc play in wound healing?
Cofactor in DNA and RNA synthesis
What effect does uncontrolled DM or hyperglycemia have on wound healing?
Impaired collagen formation
Impaired healing
Inhibits fibroblast and endothelial cell proliferation
What effects do steroids have on wound healing?
Decrease Vitamin A
Alter remodeling and deposition of collagen
What effect does smoking have on wound healing?
Lowered O2 capacity in hemoglobin
Decreased collagen formation
Which stage of pressure ulcer has full thickness skin loss?
Stage 3
What characterizes stage 1 pressure ulcers?
Unblanchable erythema
In treating pressure ulcers, how do hydrocolloid dressings work?
- For an occlusive barrier over ulcer. Maintain moist environment to prevent infection.
- Prevent shearing
- Stage 1, 2, 3 and some stage 4 ulcers with no necrotic tissue and minimal exudate
In treating pressure ulcers, how do transparent adhesive dressings work?
- Moist environment
- Promote epithelialization
- Stage 1, 2, and 3 with no necrotic tissue and minimal exudate
In treating pressure ulcers, how do alginate dressings work?
- From brown seaweed
- Light to heavily draining stage 2, 3, and 4 ulcers
- Infected and non-infected wounds
- Not for dry wounds (delay healing)
What are the most common chronic wounds in adults?
Venous stasis ulcers
Which malleolus is usually affected in venous insufficiency?
Medial malleolus
Treatment of venous stasis ulcers?
Elevation
Compression
+/- Debridement +/- ABX
Vein ligation
What are the 5 P’s?
Pulselessness, pallor, pain, paresthesias, paralysis
What causes arterial insufficiency?
Atherosclerosis
Where do arterial insufficiency ulcers typically occur?
Toes
Anywhere on ankle, leg or foot
Tx for claudication?
Walking around: revascularization
Tx for arterial insufficiency?
Walking around
25% heal on own
Amputation
What type of scar grows beyond the original boundaries of the wound?
Keloid
Seen in darker skin
Complications of excising a keloid scar?
50-80% recurrence
Treatment for a hypertrophic scar?
- Excision if original closure was unusual
- Steroid injections
What condition causes Charcot foot?
Diabetic neuropathy
What does SSI stand for?
Surgical site infection
Treatment for a superficial abscess after surgery?
Reopen wound
+/- oral antibiotics
Treatment for surgical infections of organs/ intracavitary spaces?
IV antibiotics
Drainage
What is a big risk in deep incisional surgical site infections?
Fascial necrosis
Dehiscence
Hernia
What kind of surgical infection case is characterized by the following: abscess; preoperative perforation of biliary, respiratory, GI, or GU tract; penetrating wound >4 hours old?
Dirty case
Which type of case are most surgical infections?
Contaminated
When should we use ABX for clean wound surgery?
If prosthesis involved
Which type of surgical wound infections require pre-op ABX?
Clean contaminated
Contaminated
Dirty