Wound Healing Flashcards
What are the phases of wound healing?
Inflammation
Proliferation
Maturation/ re modeling
What is the goal of inflammation?
Control bleeding and fight infectious agents
What are the cardinal signs of inflammation?
Edema, redness, warmth, pain, and decreased function
What are the first cells to the site of the injury?
PMNs
What do PMNs do?
Kill bacteria and clean wound
What do macrophages do in the inflammation process?
Kill pathogens and direct the repair process
What do mast cells do in the inflammation process?
Produce histamine and secrete enzymes to accelerate riddance of damaged cells
What are the key cells in inflammation?
Platelets, PMNs, macrophages, and mast cells
What are the key cells in proliferation?
Angioblasts, fibroblasts, myofibroblasts, and keratinocyte
What is angiogenesis?
Formation of new blood vessels
What is granulation tissue?
When fibroblasts lay down extracellular matrix
What is wound contraction?
Myofibroblasts pull wound margins together
What is epithelization?
Keratinocytes and epidermal appendages multiply and migrate across wound bed
How long does maturation take following wound closure?
2 years (greatest change in first 6-12 months)
What % of tissue strength is reached after maturation?
80%
What happens with scar tissue when a wound is fully healed?.
Unable to sweat and less sensitive to touch and temperature
What is primary intention wound closure?
Wound edges are approximated without formation of granulation tissue (unlikely in PT)
What is secondary intention wound closure?
Wound edges unable to be approximated and granulation tissue fills in wound bed (likely in PT)
What is the DIME acronym in wound bed preparation?
Debridement
Inflammation/infection
Moisture balance
Edge effect
