Wound healing

Question 1

pressure sore development

Answer 1

Cycle of pressure (causing ischemia) and repercussion (causing edema, tissue damage, inc ROS)

Question 2

urosepsis caused by E coli. What componenet makes pt septic?

Answer 2

Lipid A

Question 3

process of intestinal anastomtic healing due to collagen

Answer 3

within the first 24 hours mature collagen is both depostied and degraded. breakdown of collagen due to MMP (collagenase) and the inhibtion of MMP increases strength of anastomoses

Question 4

cancer cachexia common in advnaced malignancy. mediated by?

Answer 4

tumor necrosis factor alpha

Question 5

First step in activation of extrinsic pathway of apoptosis?

Answer 5

binding of deth receptors

Question 6

1st phase of wound healing: Inflammation

Answer 6

1-10 days; PMNs, Macros, TNFa, IL1, PDGF

Question 7

2nd phase of wound healing: proliferation

Answer 7

5days-3weeks; fibroblasts deposit collagen, novas, typeIII replaced Type I;
epitheliaziation (1-2mm/day), FGF and EGF

Question 8

3rd phase of wound healing: maturation

Answer 8

3weeks - 1 year; collagen crosslinking

Question 9

negative pressure wound therapy

Answer 9

promotes granulation tissue

Question 10

skin grafts heal by (3)

Answer 10

Imibition, inosculation, revascularization

Question 11

Facts about leukotrienes

Answer 11

1. from Arachidonic acid
2. inc cap permeability
3. release Platelet agg factor
   (think about it like slow rxn anaphylaxis)

Question 12

known to be protein marker for schwannoma and neurofibroma, which following is associated with melanoma?

Answer 12

S 100