Work-up & Staging Flashcards
What is the workup for suspected glioma?
Suspected glioma workup: H&P, basic labs, and MRI brain
How should tissue be acquired for Dx?
Tissue should be acquired by max safe resection (per the NCCN), otherwise by stereotactic Bx.
What is the typical MRI characteristic seen in LGG?
On MRI, LGGs appear hypointense on T1, are nonenhancing with gadolinium, and show T2 prolongation.
What is the typical MRI appearance of pilocytic astrocytoma?
Well-circumscribed, cystic mass, intensely enhancing solid mural nodule
What % of nonenhancing lesions are grade III gliomas?
∼30% are grade III gliomas (65% are LGG).
What feature has been associated with oligodendrogliomas on imaging?
Calcifications are a prominent feature on imaging of oligodendrogliomas.
What is suggestive of a malignant tumor on MR spectroscopy?
Increased choline (cell membrane marker), low creatine (energy metabolite), and low N-acetyl-aspartate (a neuronal marker) are suggestive of malignancy on MR spectroscopy.
What is the staging of LGG?
There is no formal staging for LGG.
What is the workup for suspected glioma?
Suspected glioma workup: H&P, basic labs, and MRI brain
How should tissue be acquired for Dx?
Tissue should be acquired by max safe resection (per the NCCN), otherwise by stereotactic Bx.
What is the typical MRI characteristic seen in LGG?
On MRI, LGGs appear hypointense on T1, are nonenhancing with gadolinium, and show T2 prolongation.
What is the typical MRI appearance of pilocytic astrocytoma?
Well-circumscribed, cystic mass, intensely enhancing solid mural nodule
What % of nonenhancing lesions are grade III gliomas?
∼30% are grade III gliomas (65% are LGG).
What feature has been associated with oligodendrogliomas on imaging?
Calcifications are a prominent feature on imaging of oligodendrogliomas.
What is suggestive of a malignant tumor on MR spectroscopy?
Increased choline (cell membrane marker), low creatine (energy metabolite), and low N-acetyl-aspartate (a neuronal marker) are suggestive of malignancy on MR spectroscopy.
